Inheritance of diabetes mellitus in Keeshond dogs
1988; American Veterinary Medical Association; Volume: 49; Issue: 3 Linguagem: Inglês
10.2460/ajvr.1988.49.03.428
ISSN1943-5681
AutoresJohn W. Kramer, Julieta Klaassen, Denis G. Baskin, David J. Prieur, Norman W. Rantanen, Jack D. Robinette, Wanda R. Graber, Linda Rashti,
Tópico(s)Pancreatic function and diabetes
ResumoThe genetic aspects of inherited, insulin-dependent diabetes mellitus of Keeshond dogs were studied retrospectively and in a prospective mating program. The symbol dm was used to designate the gene that causes hypoplasia of the islets of Langerhans. The retrospective study disclosed 4 diabetic dogs; prospective outcross, backcross, and inbred matings disclosed 49 diabetic dogs. Outcrossing demonstrated that the diabetic phenotype was displayed readily against a genetic background of a breed other than the Keeshond. In dogs with the dm/dm genotype, onset of diabetes was most frequent before the dog was 6 months old, but did occur in some older dogs. The dm genotype was best described as autosomal recessive.
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