Portal de Periódicos da CAPES

Myeloperoxidase activity in blood plasma as a criterion of therapy for patients with cardiovascular disease

2016; Volume: 62; Issue: 3 Linguagem: Inglês

10.18097/pbmc20166203318

2310-6972

D. V. Grigorieva, И. В. Горудко, В. А. Костевич, Sokolov Av, И. В. Буко, V. B. Vasilyev, L. Z. Polonetsky, О. М. Панасенко, С. Н. Черенкевич,

Medical and Biological Ozone Research

A significant increase in the myeloperoxidase (MPO) activity has been found in plasma of patients with stable angina and with acute coronary syndrome (ACS) in comparison with the control group. MPO concentration was significantly increased in plasma of ACS patients. Reduced MPO activity in the treated ACS patients correlated with a favorable outcome of the disease. Generally, changes in plasma MPO concentration coincided with changes in lactoferrin concentration thus confirming the role of neutrophil degranulation in the increase of plasma concentrations of these proteins. The increase in MPO activity was obviously determined by modification of the MPO protein caused by reactive oxygen species and halogen in the molar ratio of 1 : 25 and 1 : 50. The decrease in plasma MPO activity may be associated with increased plasma concentrations of the physiological inhibitor of its activity, ceruloplasmin, and also with modification of the MPO protein with reactive oxygen species and halogen at their molar ratio of 1 : 100 and higher. Thus, MPO activity may be used for evaluation of effectiveness of the treatment of cardiovascular diseases. Vyiavleno dostovernoe uvelichenie aktivnosti mieloperoksidazy (MPO) v plazme krovi bol'nykh kak so stabil'noĭ stenokardieĭ, tak i s ostrym koronarnym sindromom (OKS) po sravneniiu s kontrol'noĭ gruppoĭ. Kontsentratsiia MPO dostoverno uvelichena v plazme krovi bol'nykh s OKS. Snizhenie aktivnosti MPO v protsesse lecheniia bol'nykh s OKS korreliruet s blagopriiatnym iskhodom zabolevaniia. Izmenenie kontsentratsii MPO v tselom sovpadaet s izmeneniem kontsentratsii laktoferrina, chto podtverzhdaet rol' degranuliatsii neĭtrofilov v povyshenii kontsentratsii dannykh belkov v plazme krovi. Uvelichenie aktivnosti MPO obuslovleno modifikatsieĭ belkovoĭ chasti molekuly aktivnymi formami kisloroda i galogenov v mol'nom sootnoshenii 1:25 i 1:50. Snizhenie aktivnosti MPO, s odnoĭ storony, sviazano s uvelicheniem v plazme krovi aktivnosti ee fiziologicheskogo ingibitora – tseruloplazmina, s drugoĭ storony, obuslovleno modifikatsieĭ fermenta aktivnymi formami kisloroda i galogenov v mol'nom sootnoshenii 1:100 i vyshe. Pokazana rol' monitoringa aktivnosti MPO dlia otsenki éffektivnosti terapii serdechno-sosudistykh zabolevaniĭ.