Portal de Periódicos da CAPES

The Exocyst at a Glance

2015; The Company of Biologists; Linguagem: Inglês

10.1242/jcs.156398

1477-9137

Bin Wu, Wei Guo,

Nuclear Structure and Function

The exocyst is an octameric protein complex that is implicated in the tethering of secretory vesicles to the plasma membrane prior to SNARE-mediated fusion. Spatial and temporal control of exocytosis through the exocyst has a crucial role in a number of physiological processes, such as morphogenesis, cell cycle progression, primary ciliogenesis, cell migration and tumor invasion. In this Cell Science at a Glance poster article, we summarize recent works on the molecular organization, function and regulation of the exocyst complex, as they provide rationales to the involvement of this complex in such a diverse array of cellular processes.