Portal de Periódicos da CAPES

Pd II and Pt II complexes with a thio-aza macrocycle ligand containing an intercalating fragment: Structural and antitumor activity studies

2016; Elsevier BV; Volume: 162; Linguagem: Inglês

10.1016/j.jinorgbio.2016.06.027

1873-3344

Stefano Amatori, Gianluca Ambrosi, Alfredo Errico Provenzano, Mirco Fanelli, Mauro Formica, Vieri Fusi, Luca Giorgi, Eleonora Macedi, Mauro Micheloni, Paola Paoli, Patrizia Rossi,

Crystal structures of chemical compounds

Two new PtII and PdII complexes of formula [LMCl2] (M=Pt, Pd) were synthesized and characterized both in solution and solid state. They were obtained using the thio-aza macrocycle 9,18-dimethyl-12,17dithia-9,18,27,28-tetraaaza-29-oxatetracyclo[24.2.1.02,7.020,25]enneicosa-2,4,6,20,22,24,26,281-octaene (L) containing the 2,5-diphenyl [1, 3, 4]oxadiazole as intercalating fragment. MII is coordinated in cis-position by the two S atoms of L. The two crystal structures of [LPtCl2] and [LPdCl2] complexes showed that the MII ion is located outside the macrocyclic cavity. The square planar coordination sphere is fulfilled by two chloride anions in a cisplatin-like arrangement with the chloride leaving groups exposed to the environment. The biological activity of both [LPtCl2] and [LPdCl2], monitored towards a leukemic cellular model (U937), is coherent with their ability to interfere, at different levels, with the DNA structure.