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J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

2016; Elsevier BV; Volume: 13; Issue: 10 Linguagem: Inglês

10.1016/j.hrthm.2016.05.024

1556-3871

Charles Antzelevitch, Gan-Xin Yan, Michael J. Ackerman, Martin Borggrefe, Domenico Corrado, Jihong Guo, Ihor Gussak, Can Hasdemir, Minoru Horie, Heikki V. Huikuri, Changsheng Ma, Hiroshi Morita, Gi‐Byoung Nam, Frédéric Sacher, Wataru Shimizu, Sami Viskin, Arthur A.M. Wilde,

Cardiac Arrhythmias and Treatments

The J-wave syndromes (JWSs), consisting of the Brugada syndrome (BrS) and early repolarization syndrome (ERS), have captured the interest of the cardiology community over the past 2 decades following the identification of BrS as a new clinical entity by Pedro and Josep Brugada in 1992. 1 Brugada P. Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome: a multicenter report. J Am Coll Cardiol. 1992; 20: 1391-1396 Abstract Full Text PDF PubMed Scopus (0) Google Scholar The clinical impact of ERS was not fully appreciated until 2008. 2 Haissaguerre M. Derval N. Sacher F. et al. Sudden cardiac arrest associated with early repolarization. N Engl J Med. 2008; 358: 2016-2023 Crossref PubMed Scopus (705) Google Scholar , 3 Nam G.B. Kim Y.H. Antzelevitch C. Augmentation of J waves and electrical storms in patients with early repolarization. N Engl J Med. 2008; 358: 2078-2079 Crossref PubMed Scopus (0) Google Scholar , 4 Rosso R. Kogan E. Belhassen B. Rozovski U. Scheinman M.M. Zeltser D. Halkin A. Steinvil A. Heller K. Glikson M. Katz A. Viskin S. J-point elevation in survivors of primary ventricular fibrillation and matched control subjects: incidence and clinical significance. J Am Coll Cardiol. 2008; 52: 1231-1238 Abstract Full Text Full Text PDF PubMed Scopus (310) Google Scholar Consensus conferences dedicated to BrS were held in 2000 and 2004, 5 Wilde A.A. Antzelevitch C. Borggrefe M. Brugada J. Brugada R. Brugada P. Corrado D. Hauer R.N. Kass R.S. Nademanee K. Priori S.G. Towbin J.A. Proposed diagnostic criteria for the Brugada syndrome: consensus report. Circulation. 2002; 106: 2514-2519 Crossref PubMed Scopus (522) Google Scholar , 6 Antzelevitch C. Brugada P. Borggrefe M. et al. Brugada syndrome: report of the second consensus conference: endorsed by the Heart Rhythm Society and the European Heart Rhythm Association. Circulation. 2005; 111: 659-670 Crossref PubMed Scopus (979) Google Scholar but a consensus conference specifically focused on ERS has not previously been convened other than that dealing with terminology, and guidelines for both syndromes were last considered in 2013. 7 Priori S.G. Wilde A.A. Horie M. et al. Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Heart Rhythm. 2013; 15: 1389-1406 Google Scholar A great deal of new information has emerged since. The present forum was organized to evaluate new information and highlight emerging concepts with respect to differential diagnosis, prognosis, cellular and ionic mechanisms, and approaches to therapy of the JWSs. Leading experts, including members of the Heart Rhythm Society (HRS), the European Heart Rhythm Association (EHRA), and the Asian-Pacific Heart Rhythm Society (APHRS), met in Shanghai, China, in April 2015. The Task Force was charged with a review of emerging concepts and assessment of new evidence for or against particular diagnostic procedures and treatments. Every effort was made to avoid any actual, potential, or perceived conflict of interest that might arise as a result of outside relationships or personal interest. This consensus report is intended to assist health care providers in clinical decision-making. The ultimate judgment regarding care of a particular patient, however, must be made by the health care provider based on all of the facts and circumstances presented by the patient.