Voltar
Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Photochemical and Electrochemical Study of the Release of Nitric Oxide from [Ru(bpy) 2 L(NO)](PF 6 ) n Complexes (L = Imidazole, 1-Methylimidazole, Sulfite and Thiourea), Toward the Development of Therapeutic Photodynamic Agents

2015; Brazilian Chemical Society; Linguagem: Inglês

10.5935/0103-5053.20150159

ISSN

1678-4790

Autores

Manuela C. L. Cândido, Arquimedes M. Oliveira, Francisco O. N. Silva, Alda K.M. Holanda, Walysson Gomes Pereira, Eduardo H. S. Sousa, Zumira Aparecida Carneiro, Roberto S. Silva, Luiz Gonzaga de França Lopes,

Tópico(s)

Electrochemical Analysis and Applications

Resumo

The development of NO photoreleaser compounds has important potential applications on medicine, particularly on preventing topic infections and controlling cancers.Due to these expectations, the photochemical release of nitric oxide from complexes of [Ru(bpy) 2 LX] n+ , where L = imidazole, 1-methylimidazole, sulphite and thiourea and X = NO + and NO 2 -was investigated employing spectroscopic and electrochemical techniques.The release of NO was confirmed by chronoamperometry using a NO selective electrode, while the other product, mainly [Ru II H 2 O], was detected by UV-Visible spectroscopy and electrochemical techniques for all complexes except for thiourea.The amount of NO released by these complexes upon irradiation was determined using a new developed method using square wave voltammetry.

Referência(s)