Encapsulation of a Nerve Agent Detoxifying Enzyme by a Mesoporous Zirconium Metal–Organic Framework Engenders Thermal and Long-Term Stability
2016; American Chemical Society; Volume: 138; Issue: 26 Linguagem: Inglês
10.1021/jacs.6b03673
ISSN1943-2984
AutoresPeng Li, Su‐Young Moon, Mark A. Guelta, Steven P. Harvey, Joseph T. Hupp, Omar K. Farha,
Tópico(s)Dendrimers and Hyperbranched Polymers
ResumoImmobilized enzymes typically have greater thermal and operational stability than their soluble form. Here we report that for the first time, a nerve agent detoxifying enzyme, organophosphorus acid anhydrolase (OPAA), has been successfully encapsulated into a water-stable zirconium metal–organic framework (MOF). This MOF features a hierarchical mesoporous channel structure and exhibits a 12 wt % loading capacity of OPAA. The thermal and long-term stabilities of OPAA are both significantly enhanced after immobilization.
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