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A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms

2016; Massachusetts Medical Society; Volume: 374; Issue: 25 Linguagem: Inglês

10.1056/nejmoa1513137

1533-4406

Didier Ménard, Nimol Khim, Johann Beghain, Ayôla Akim Adégnika, Mohammad Shafiul Alam, Olukemi K. Amodu, Ghulam Rahim-Awab, Céline Barnadas, Antoine Berry, Yap Boum, Maria Dorina Bustos, Jun Cao, Jun-Hu Chen, Louis Collet, Liwang Cui, Garib-Das Thakur, Alioune Dièye, Djibrine Djallé, Améyo M. Dorkenoo, Carole E. Eboumbou-Moukoko, Fe-Esperanza-Caridad J. Espino, Thierry Fandeur, Maria-Fatima Ferreira-da-Cruz, Abebe A. Fola, Hans‐Peter Fuehrer, Abdillahi Mohamed Hassan, Sócrates Herrera, Bouasy Hongvanthong, Sandrine Houzé, Maman Laminou Ibrahim, Mohammad Jahirul-Karim, Lubin Jiang, Shigeyuki Kano, Wasif Ali-Khan, Maniphone Khanthavong, Peter G. Kremsner, Marcus Lacerda, Rithea Leang, Mindy Leelawong, Li Mei, Khin Lin, Jean-Baptiste Mazarati, Sandie Ménard, Isabelle Morlais, Hypolite Muhindo Mavoko, L. Musset, Kesara Na–Bangchang, Michael Nambozi, Karamoko Niaré, Harald Noedl, Jean‐Bosco Ouédraogo, Dylan R. Pillai, Bruno Pradines, Bui Quang-Phuc, Michael Ramharter, Milijaona Randrianarivelojosia, Jetsumon Sattabongkot, Abdiqani Sheikh-Omar, Kigbafori D. Silué, Sodiomon B. Sirima, Colin J. Sutherland, Din Syafruddin, Rachida Tahar, Lin-Hua Tang, Offianan André Touré, Patrick Tshibangu-wa-Tshibangu, Inès Vigan-Womas, Marian Warsame, Lyndes Wini, Sedigheh Zakeri, Saorin Kim, Rotha Eam, Laura Berne, Chanra Khean, Sophy Chy, Malen Ken, Kaknika Loch, Lydie Canier, Valentine Duru, Eric Legrand, Jean-Christophe Barale, Barbara H. Stokes, Judith Straimer, Benoît Witkowski, David A. Fidock, Christophe Rogier, Pascal Ringwald, Frédéric Ariey, Odile Mercereau‐Puijalon,

Research on Leishmaniasis Studies

Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P. falciparum gene encoding kelch (K13)–propeller domains are the major determinant of resistance has provided opportunities for monitoring such resistance on a global scale.