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The Effects of Castration on Adrenal Testosterone Secretion in Men with Prostatic Carcinoma

1977; Lippincott Williams & Wilkins; Volume: 118; Issue: 6 Linguagem: Inglês

10.1016/s0022-5347(17)58283-x

1527-3792

E.J. Sanford, David F. Paulson, Thomas J. Rohner, Joseph R. Drago, Richard J. Santen, C. Wayne Bardin,

Sexual Differentiation and Disorders

No AccessJournal of Urology1 Dec 1977The Effects of Castration on Adrenal Testosterone Secretion in Men with Prostatic Carcinoma E.J. Sanford, D.F. Paulson, T.J. Rohner, J.R. Drago, R.J. Santen, and C.W. Bardin E.J. SanfordE.J. Sanford More articles by this author , D.F. PaulsonD.F. Paulson More articles by this author , T.J. RohnerT.J. Rohner More articles by this author , J.R. DragoJ.R. Drago More articles by this author , R.J. SantenR.J. Santen More articles by this author , and C.W. BardinC.W. Bardin Recipient of a Faculty Scholar Award from the Josiah Macy, Jr. Foundation. More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)58283-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Selective adrenal vein catheterization was done on intact and castrated men with prostatic carcinoma. Adrenal to peripheral venous testosterone gradients were observed in all patients, indicating adrenal production of this hormone. No compensatory adrenal production of testosterone was noted during a 17-month period after orchiectomy. The data suggest that the human adrenal in castrates produces testosterone, which may explain why adrenal ablation can offer palliation in some patients with prostatic carcinoma. © 1977 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byHudson P, Hakky S and Lombardo M (2018) Testicular Androgens in Prostate Cancer Patients Treated with a Luteinizing Hormone Releasing Hormone AgonistJournal of Urology, VOL. 151, NO. 5, (1281-1282), Online publication date: 1-May-1994.Dupont A, Gomez J, Cusan L, Koutsilieris M and Labrie F (2018) Response to Flutamide Withdrawal in Advanced Prostate Cancer in Progression Under Combination TherapyJournal of Urology, VOL. 150, NO. 3, (908-913), Online publication date: 1-Sep-1993.Smith J (2018) New Methods of Endocrine Management of Prostatic CancerJournal of Urology, VOL. 137, NO. 1, (1-10), Online publication date: 1-Jan-1987.Oesterling J, Epstein J and Walsh P (2018) The Inability of Adrenal Androgens to Stimulate the Adult Human Prostate: An Autopsy Evaluation of Men with Hypogonadotropic Hypogonadism and PanhypopituitarismJournal of Urology, VOL. 136, NO. 5, (1030-1034), Online publication date: 1-Nov-1986.Worgul T, Santen R, Samojlik E, Veldhuis J, Lipton A, Harvey H, Drago J and Rohner T (2018) Clinical and Biochemical Effect of Aminoglutethimide in the Treatment of Advanced Prostatic CarcinomaJournal of Urology, VOL. 129, NO. 1, (51-55), Online publication date: 1-Jan-1983. Volume 118Issue 6December 1977Page: 1019-1021 Advertisement Copyright & Permissions© 1977 by The American Urological Association Education and Research, Inc.MetricsAuthor Information E.J. Sanford More articles by this author D.F. Paulson More articles by this author T.J. Rohner More articles by this author J.R. Drago More articles by this author R.J. Santen More articles by this author C.W. Bardin Recipient of a Faculty Scholar Award from the Josiah Macy, Jr. Foundation. More articles by this author Expand All Advertisement PDF downloadLoading ...