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Metastatic Cancer of the Prostate Managed with Buserelin Versus Buserelin Plus Cyproterone Acetate

1987; Lippincott Williams & Wilkins; Volume: 137; Issue: 5 Linguagem: Inglês

10.1016/s0022-5347(17)44293-5

1527-3792

Fritz H. Schroeder, Tycho Lock, Dev R. Chadha, F.M.J. Debruyne, Herbert F.M. Karthaus, Frank H. de Jong, Jan G.M. Klijn, A.W. Matroos, H. J. de Voogt,

Hormonal and reproductive studies

No AccessJournal of Urology1 May 1987Metastatic Cancer of the Prostate Managed with Buserelin Versus Buserelin Plus Cyproterone Acetate Fritz H. Schroeder, Tycho M.T.W. Lock, Dev R. Chadha, Frans M.J. Debruyne, Herbert F.M. Karthaus, Frank H. de Jong, Jan G.M. Klijn, Ans W. Matroos, and Herman J. de Voogt Fritz H. SchroederFritz H. Schroeder , Tycho M.T.W. LockTycho M.T.W. Lock , Dev R. ChadhaDev R. Chadha , Frans M.J. DebruyneFrans M.J. Debruyne , Herbert F.M. KarthausHerbert F.M. Karthaus , Frank H. de JongFrank H. de Jong , Jan G.M. KlijnJan G.M. Klijn , Ans W. MatroosAns W. Matroos , and Herman J. de VoogtHerman J. de Voogt View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)44293-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail We recruited 71 previously untreated patients with metastatic prostatic carcinoma to 2 separate consecutive prospective phase 2 studies done by the same group of investigators according to the same protocols in which only the treatment regimens differed. Of the patients 58 were treated with the luteinizing hormone-releasing hormone analogue buserelin alone (0.4mg. 3 times daily intranasally) and 13 were treated with buserelin combined with cyproterone acetate, a potent antiandrogen (50mg. 3 times daily orally). The objective of the study was to investigate the efficacy, safety and tolerability of the medication used during at least 12 months by studying adequate endocrine parameters, the rate and duration of response, as well as the rate of progression and possible side effects. All endocrine parameters were studied in 1 laboratory. Modified response criteria of the National Prostatic Cancer Project were used. The endocrine studies showed an effective suppression of plasma testosterone to castration levels by buserelin after an initial increase during the first 2 weeks. Luteinizing hormone and follicle-stimulating hormones were lowered significantly and could not be re-stimulated by the intravenous application of luteinizing hormone-releasing hormone. There was no correlation of plasma testosterone with response and progression. However, a significant correlation existed between higher basal cortisol levels at entry, and after 3 and 6 months, and progression. Response is reported for all patients at the 12-month interval and did not seem to differ among treatment groups. The rate of progression after all patients had been treated for 1 year was 37.9 per cent in the buserelin group and 41 per cent in the buserelin plus cyproterone acetate group. Three early deaths occurred in the buserelin group. Except for impotence, only mild side effects were noted. Our study shows that treatment of metastatic prostatic cancer by means of the luteinizing-hormone-releasing hormone analogue buserelin is safe and effective. The results obtained are compatible with those obtained by castration. In our study a superiority of total androgen withdrawal over testicular suppression alone could not be shown. © 1987 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByAPPU S, LAWRENTSCHUK N, GRILLS R and NEERHUT G (2018) EFFECTIVENESS OF CYPROTERONE ACETATE IN ACHIEVING CASTRATION AND PREVENTING LUTEINIZING HORMONE RELEASING HORMONE ANALOGUE INDUCED TESTOSTERONE SURGE IN PATIENTS WITH PROSTATE CANCERJournal of Urology, VOL. 174, NO. 1, (140-142), Online publication date: 1-Jul-2005.Goldenberg S, Bruchovsky N, Rennie P and Coppin C (2018) The Combination of Cyproterone Acetate and Low Dose Diethylstilbestrol in the Treatment of Advanced Prostatic CarcinomaJournal of Urology, VOL. 140, NO. 6, (1460-1465), Online publication date: 1-Dec-1988. Volume 137Issue 5May 1987Page: 912-918 Advertisement Copyright & Permissions© 1987 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Fritz H. Schroeder More articles by this author Tycho M.T.W. Lock More articles by this author Dev R. Chadha More articles by this author Frans M.J. Debruyne More articles by this author Herbert F.M. Karthaus More articles by this author Frank H. de Jong More articles by this author Jan G.M. Klijn More articles by this author Ans W. Matroos More articles by this author Herman J. de Voogt More articles by this author Expand All Advertisement PDF DownloadLoading ...