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BIBTEX RIS

Whole Genome Phylogeny of Bacillus by Feature Frequency Profiles (FFP)

2015; Nature Portfolio; Volume: 5; Issue: 1 Linguagem: Inglês

10.1038/srep13644

ISSN

2045-2322

Autores

Aisuo Wang, Gavin Ash,

Tópico(s)

Genomics and Phylogenetic Studies

Resumo

Abstract Fifty complete Bacillus genome sequences and associated plasmids were compared using the “feature frequency profile” (FFP) method. The resulting whole-genome phylogeny supports the placement of three Bacillus species ( B. thuringiensis, B. anthracis and B. cereus ) as a single clade. The monophyletic status of B. anthracis was strongly supported by the analysis. FFP proved to be more effective in inferring the phylogeny of Bacillus than methods based on single gene sequences [16s rRNA gene, GryB (gyrase subunit B) and AroE (shikimate-5-dehydrogenase)] analyses. The findings of FFP analysis were verified using kSNP v2 (alignment-free sequence analysis method) and Harvest suite (core genome sequence alignment method).

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