Association of a chromosomal 3;21 translocation with the blast phase of chronic myelogenous leukemia
1987; Elsevier BV; Volume: 70; Issue: 5 Linguagem: Inglês
10.1182/blood.v70.5.1338.1338
ISSN1528-0020
AutoresCM Rubin, Richard A. Larson, MA Bitter, JJ Carrino, MM Le Beau, MO Diaz, JD Rowley,
Tópico(s)Acute Myeloid Leukemia Research
ResumoAbstract An identical reciprocal translocation between the long arms of chromosomes 3 and 21 with breakpoints in bands 3q26 and 21q22, t(3;21)(q26;q22), was found in three male patients with the blast phase of chronic myelogenous leukemia (CML). The abnormality was clonal in all three patients and was always accompanied by either a standard or variant 9;22 translocation resulting in a Philadelphia chromosome (Ph1). In two cases, the t(3;21) was the only abnormality other than a t(9;22) in the primary clone. Serial studies of one patient demonstrated that the t(3;21) occurred as a result of clonal evolution near the time of development of the blast phase. We have not observed the t(3;21) in greater than 500 patients with CML in the chronic phase. Thus, the t(3;21) is a new recurring cytogenetic abnormality associated with the blast phase of CML.
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