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BIBTEX RIS

Controlled Release of Nor-β-lapachone by PLGA Microparticles: A Strategy for Improving Cytotoxicity against Prostate Cancer Cells

2016; Multidisciplinary Digital Publishing Institute; Volume: 21; Issue: 7 Linguagem: Inglês

10.3390/molecules21070873

ISSN

1433-1373

Autores

Marcília Pinheiro da Costa, Anderson C. S. Feitosa, Fátima Oliveira, Bruno C. Cavalcanti, Eufrânio N. da Silva Júnior, Gleiston G. Dias, F. A. M. Sales, Bruno Sousa, Ito L. Barroso-Neto, Cláudia Pessoa, E. W. S. Caetano, Stefano Fiore, Rainer Fischer, Luiz O. Ladeira, V. N. Freire,

Tópico(s)

Cancer therapeutics and mechanisms

Resumo

Prostate cancer is one of the most common malignant tumors in males and it has become a major worldwide public health problem. This study characterizes the encapsulation of Nor-β-lapachone (NβL) in poly(d,l-lactide-co-glycolide) (PLGA) microcapsules and evaluates the cytotoxicity of the resulting drug-loaded system against metastatic prostate cancer cells. The microcapsules presented appropriate morphological features and the presence of drug molecules in the microcapsules was confirmed by different methods. Spherical microcapsules with a size range of 1.03 ± 0.46 μm were produced with an encapsulation efficiency of approximately 19%. Classical molecular dynamics calculations provided an estimate of the typical adsorption energies of NβL on PLGA. Finally, the cytotoxic activity of NβL against PC3M human prostate cancer cells was demonstrated to be significantly enhanced when delivered by PLGA microcapsules in comparison with the free drug.

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