The Development of Tumors in Experimental Gastroenterocystoplasty
1993; Lippincott Williams & Wilkins; Volume: 150; Issue: 2 Part 2 Linguagem: Inglês
10.1016/s0022-5347(17)35599-4
ISSN1527-3792
AutoresHélio Buson, David Castro‐Díaz, J. Carlos Manivel, José Jessurun, Murat Dayanç, Ricardo González,
Tópico(s)Bladder and Urothelial Cancer Treatments
ResumoNo AccessJournal of Urology1 Aug 1993The Development of Tumors in Experimental Gastroenterocystoplasty Hélio Buson, David Castro Diaz, J. Carlos Manivel, Jose Jessurun, Murat Dayanc, and Ricardo Gonzalez Hélio BusonHélio Buson , David Castro DiazDavid Castro Diaz , J. Carlos ManivelJ. Carlos Manivel , Jose JessurunJose Jessurun , Murat DayancMurat Dayanc , and Ricardo GonzalezRicardo Gonzalez View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)35599-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Bladder augmentation with segments of the gastrointestinal tract is commonly used to treat patients with small or noncompliant bladders. Reliable data on the incidence of tumors in patients with enterocystoplasty are not available. In the small number of cases reported in the literature the mean latency period is approximately 18 years. We designed a study in Sprague Dawley rats to try to determine the risk of carcinogenesis in different types of augmentation cystoplasty and its possible relationship with infected urine, and to investigate the possibility of detecting the tumors by cytological analysis. We performed 30 gastrocystoplasties, 35 sigmoid cystoplasties, 30 ileocystoplasties and 10 sham operations, and used 10 nonoperated animals as controls. The animals were sacrificed upon completing 1 year of followup and bladder urine samples were collected at the time of sacrifice. Of 115 animals 86 were available for histological evaluation (26 gastrocystoplasty, 22 sigmoid cystoplasty, 18 ileocystoplasty, and all sham and control animals). Mean followup was 11.2 months in the gastrocystoplasty, 11.8 months in the sigmoid cystoplasty, and 12 months in the ileocystoplasty, sham and control groups. Multifocal or superficial transitional metaplasia was found in 65.4% of the gastrocystoplasty, 50% of the sigmoid cystoplasty and 55.5% of the ileocystoplasty animals. Proliferations that we classified as papillary hyperplasia were present in 53.8% of the gastrocystoplasty, 40.9% of the sigmoid cystoplasty and none of the ileocystoplasty rats. The proliferations occurred either at or close to the anastomosis between the bladder and the gastric or colonic patch, or in areas of transitional metaplasia. Cytological urinalysis was negative for neoplastic cells in all cases. No correlation was found between the occurrence of papillary hyperplasia and urinary infection. These data indicate that in rats transitional metaplasia is common in gastrocystoplasty, sigmoid cystoplasty and ileocystoplasty, and that papillary hyperplasia may occur near or at the anastomosis, or in areas of transitional metaplasia in either gastrocystoplasty or sigmoid cystoplasty. In contrast to other studies, we observed no examples of papillary hyperplasia in the ileocystoplasty group in this series. No transitional cell carcinomas or adenocarcinomas were identified in this study. It is not known if these papillary lesions have an increased malignant potential, thus further studies with longer followup are warranted. © 1993 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByKispal Z, Vajda P, Kereskai L, Jakab C, Vastyan A, Juhasz Z and Pinter A (2018) Composite Urinary Reservoir in Dogs: Histological FindingsJournal of Urology, VOL. 187, NO. 3, (1110-1115), Online publication date: 1-Mar-2012.Castellan M, Gosalbez R, Perez-Brayfield M, Healey P, McDonald R, Labbie A and Lendvay T (2007) Tumor in Bladder Reservoir After GastrocystoplastyJournal of Urology, VOL. 178, NO. 4S, (1771-1774), Online publication date: 1-Oct-2007.CLOSE C, TEKGUL S, GANESAN G, TRUE L and MITCHELL M (2018) Flow Cytometry Analysis of Proliferative Lesions at the Gastrocystoplasty AnastomosisJournal of Urology, VOL. 169, NO. 1, (365-368), Online publication date: 1-Jan-2003.Vajda P, Kaiser L, Magyarlaki T, Farkas A, Vastyan A and Pinter A (2018) Histological Findings After Colocystoplasty And GastrocystoplastyJournal of Urology, VOL. 168, NO. 2, (698-701), Online publication date: 1-Aug-2002.RODÓ J, FARRÉ X and MARTÍN E (2018) CYCLOPHOSPHAMIDE-INDUCED HEMORRHAGIC CYSTITIS IN RATS THAT UNDERWENT COLOCYSTOPLASTY:: EXPERIMENTAL STUDYJournal of Urology, VOL. 165, NO. 2, (660-666), Online publication date: 1-Feb-2001.GITLIN J, WU X, SUN T, RITCHEY M and SHAPIRO E (2018) NEW CONCEPTS OF HISTOLOGICAL CHANGES IN EXPERIMENTAL AUGMENTATION CYSTOPLASTY: INSIGHTS INTO THE DEVELOPMENT OF NEOPLASTIC TRANSFORMATION AT THE ENTEROVESICAL AND GASTROVESICAL ANASTOMOSISJournal of Urology, VOL. 162, NO. 3 Part 2, (1096-1100), Online publication date: 1-Sep-1999.DUEL B, GONZALEZ R and BARTHOLD J (2018) ALTERNATIVE TECHNIQUES FOR AUGMENTATION CYSTOPLASTYJournal of Urology, VOL. 159, NO. 3, (998-1005), Online publication date: 1-Mar-1998.Denes E, Vates T, Freedman A and Gonzalez R (2018) Seromuscular Colocystoplasty Lined With Urothelium Protects Dogs from Acidosis During Ammonium Chloride LoadingJournal of Urology, VOL. 158, NO. 3, (1075-1080), Online publication date: 1-Sep-1997.Hickey D, Bakthavatsalam R, Bannon C, O'Malley K, Corr J and Little D (2018) Urological Complications of Pancreatic TransplantationJournal of Urology, VOL. 157, NO. 6, (2042-2048), Online publication date: 1-Jun-1997.Lima S, Araujo L, Vilar F, Kummer C and Lima E (2018) Combined Use of Enterocystoplasty and a New Type of Artificial Sphincter in the Treatment of Urinary IncontinenceJournal of Urology, VOL. 156, NO. 2S, (622-624), Online publication date: 1-Aug-1996.Lewis A, Gardner B, Gilbert A, Jarvis P, Wacksman J, Bove K and Sheldon C (2018) Relative Microbial Resistance of Gastric, Ileal and Cecal Bladder Augmentation in the RatJournal of Urology, VOL. 154, NO. 5, (1895-1899), Online publication date: 1-Nov-1995.McLaughlin K, Rink R, Adams M and Keating M (2018) Stomach in Combination with Other Intestinal Segments in Pediatric Lower Urinary Tract ReconstructionJournal of Urology, VOL. 154, NO. 3, (1162-1168), Online publication date: 1-Sep-1995.Lauvetz R, Monda J, Kramer S and Husmann D (2018) Urinary pH and Urea Concentration Correlate to the Bacterial Colonization rate in Gastric, Colonic, Ileal and Myoperitoneal Bladder AugmentationJournal of Urology, VOL. 154, NO. 2, (899-902), Online publication date: 1-Aug-1995.Merguerian P, Chavez D and Hakim S (2018) Grafting of Cultured Uroepithelium and Bladder Mucosa Into De-Epithelialized Segments of Colon in RabbitsJournal of Urology, VOL. 152, NO. 2 Part 2, (671-674), Online publication date: 1-Aug-1994.Little J, Klee L, Hoover D and Rink R (2018) Long-Term Histopathological Changes Observed in Rats Subjected to Augmentation CystoplastyJournal of Urology, VOL. 152, NO. 2 Part 2, (720-724), Online publication date: 1-Aug-1994. Volume 150Issue 2 Part 2August 1993Page: 730-733 Advertisement Copyright & Permissions© 1993 by The American Urological Association Education and Research, Inc.Keywordsbladderintestinemetaplasiaurinary diversionMetricsAuthor Information Hélio Buson Current address: Unidade de Cirurgia Pediátrica, Hospital de Base do D.F.—60 andar, SMHS Quadra 101—Zona Central, 70335-900 Brasília (DF), Brazil. More articles by this author David Castro Diaz More articles by this author J. Carlos Manivel More articles by this author Jose Jessurun More articles by this author Murat Dayanc More articles by this author Ricardo Gonzalez More articles by this author Expand All Advertisement Loading ...
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