Portal de Periódicos da CAPES

Safety and effectiveness of endobiliary radiofrequency ablation according to the different power and target temperature in a swine model

2016; Wiley; Volume: 32; Issue: 2 Linguagem: Inglês

10.1111/jgh.13472

1440-1746

Jae Hee Cho, Kwang Hyuck Lee, Joon Mee Kim, Yeon Suk Kim, Don Haeng Lee, Seok Jeong,

Atrial Fibrillation Management and Outcomes

Abstract Background and Aim Endobiliary radiofrequency ablation (EB‐RFA) is a new endoscopic palliation and adjunctive tool. Although EB‐RFA is performed worldwide, a possibility of iatrogenic thermal injury leading to perforation or bleeding still remains. Therefore, we aimed to assess the effects of thermal and coagulation injury after in vivo EB‐RFA using a new catheter with a temperature sensor in a swine model. Methods Twelve mini pigs were divided into four groups according to power (33 mm 10 W electrode vs. 18 mm 7 W electrode) and RFA target temperature (75°C vs. 80°C). All mini pigs underwent endoscopic retrograde cholangiography and target temperature controlled EB‐RFA for 120 s. Additional cholangiogram was taken immediately after RFA, and all pigs were sacrificed after 24 h to assess the macroscopic/microscopic RFA injury. Results Microscopic maximal injury depth and ablation area of EB‐RFA using a 33‐mm 10 W RFA electrode were significantly deeper and larger than those of EB‐RFA using an 18‐mm 7 W electrode (median; 2.7 vs. 2.1 mm, P = 0.004, 48.9 vs. 36.2 mm 2 , P = 0.016). However, there were no significant differences in microscopic ablation parameters between two different RFA target temperatures (75°C vs. 80°C). In addition, a post‐RFA cholangiogram and assessment of the resected specimen at 24 h after the RFA showed no adverse events such as perforation or bleeding. Conclusions EB‐RFA using a temperature controlled RFA catheter successfully ablates the bile duct wall without adverse events in a swine model.