Produção Nacional
Revisado por pares
Ortho-eugenol exhibits anti-nociceptive and anti-inflammatory activities
2016; Elsevier BV; Volume: 38; Linguagem: Inglês
10.1016/j.intimp.2016.06.005
ISSN1878-1705
AutoresDiogo Vilar da Fonsêca, Paula Regina Rodrigues Salgado, Humberto de Carvalho Aragão Neto, Adriana M.F.O. Golzio, Marcelo Ricardo Dutra Caldas Filho, Cynthia Germoglio Farias de Melo, Fagner Carvalho Leite, Márcia Regina Piuvezam, Liana Clébia de Morais Pordeus, José Maria Barbosa‐Filho, Reinaldo Nóbrega de Almeida,
Tópico(s)Phytochemistry and Biological Activities
ResumoOrtho-eugenol is a much used phenylpropanoid whose ability to reduce pain and inflammation has never been studied. Researching ortho-eugenol's antinociceptive and anti-inflammatory activity, and its possible mechanisms of action is therefore of interest. The administration of vehicle, ortho-eugenol (50, 75 and 100mg/kg i.p.), morphine (6mg/kg, i.p.) or dexamethasone (2mg/kg, s.c.) occurred 30min before the completion of pharmacological tests. Pretreatment with ortho-eugenol did not change motor coordination test results, but reduced the number of writhes and licking times in the writhing test and glutamate test, respectively. The reaction time from thermal stimulus was significantly increased in the hot plate test after administration of ortho-eugenol. Treatment with yohimbine reversed the antinociceptive effect of ortho-eugenol, suggesting involvement of the adrenergic system. In anti-inflammatory tests, ortho-eugenol inhibited acetic acid induced vascular permeability and leukocyte migration, reducing TNF-α and IL-1β by virtue of its suppression of NF-κB and p38 phosphorylated forms in the peritonitis test. From these results, ortho-eugenol antinociceptive effects mediated by the adrenergic system and anti-inflammatory activity through regulation of proinflammatory cytokines and phosphorylation of NF-kB and p38 become evident for the first time.
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