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Artigo Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

Indeterminate cell histiocytosis successfully treated with phototherapy

2016; UNIVERSIDADE DE SÃO PAULO; Volume: 6; Issue: 2 Linguagem: Inglês

10.4322/acr.2016.038

ISSN

2236-1960

Autores

Maria Cláudia Nogueira Zerbini, Mírian Nacagami Sotto, Fernando Peixoto Ferraz de Campos, André Abdo, Juliana Pereira, José Antônio Sanches, Jade Cury Martins,

Tópico(s)

Immunotherapy and Immune Responses

Resumo

First described in 1985, intermediate cell histiocytosis is a rare disorder of the cutaneous dendritic cell group with a varied clinical presentation and evolution. The pathologic substrate is constituted by the proliferation of indeterminate cells (ICs) that are immunophenotypically characterized by the positivity of CD1a, CD68, and faint/focal S100, plus the negativity for CD207 (langerin). The authors present the case of a healthy elderly woman who presented generalized dome-shaped reddish cutaneous nodules over her trunk, neck, face, and extremities over a period of 18 months. A laboratory and imaging work-up ruled out internal involvement. The skin biopsy was consistent with IC histiocytosis. The patient was treated with narrowband ultraviolet B phototherapy, which resulted in an excellent short-term outcome.

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