Myelodysplasia Following Treatment of Chronic Lymphocytic Leukaemia with Fludarabine
1999; Maney Publishing; Volume: 4; Issue: 6 Linguagem: Inglês
10.1080/10245332.1999.11746476
ISSN1607-8454
AutoresB. J. Hennessy, Sarah Ryley, A. Kasprzyk, C. D. L. Reid,
Tópico(s)Acute Lymphoblastic Leukemia research
ResumoRecently there has been an increased awareness of a possible link between the use of purine nucleoside analogues and myelodysplasia. We report the case of a patient who developed myelodysplasia with complex cytogenetic changes after receiving fludarabine. We review the literature, discuss the possible links between myelodysplasia and nucleoside analogues and putative mechanisms for secondary neoplasia.
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