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Hospital Incidence and Mortality Rates of Sepsis: An Analysis of Hospital Episode (DRG) Statistics in Germany From 2007 to 2013

2016; Deutscher Ärzte-Verlag; Linguagem: Inglês

10.3238/arztebl.2016.0159

1866-0452

Carolin Fleischmann-Struzek, Daniel Thomas-Rüddel, Michael Hartmann, Christiane S. Hartog, Tobias Welte, Steffen Heublein, U. Dennler, Konrad Reinhart,

Healthcare cost, quality, practices

Background: Sepsis, the most severe manifestation of acute infection, poses a major challenge to health care systems around the world.To date, adequate data on the incidence and mortality of sepsis in Germany have been lacking.Methods: Nationwide case-related hospital DRG statistics for the years 2007-2013 were used to determine the in-hospital incidence and mortality of sepsis.Cases were identified on the basis of the clinical and pathogen-based ICD-10 codes for sepsis.The statistical evaluation was standardized for age and sex and carried out separately for each age group.Results: The number of cases of sepsis rose by an average of 5.7% per year, from 200 535 in 2007 to 279 530 in 2013, corresponding to an increase in the adjusted in-hospital incidence from 256 to 335 cases per 100 000 persons per year.The percentage of patients with severe sepsis rose from 27% to 41%.The in-hospital mortality of sepsis fell over the same period by 2.7%, to 24.3%.In 2013, 67 849 persons died of sepsis in German hospitals (or died of another disease, but also had sepsis).The incidence was highest in the youngest and oldest age groups, and the in-hospital mortality rose nearly linearly with age from age 40 onward.Conclusion: Sepsis and death from sepsis are markedly more common in Germany than previously assumed, and they are on the rise.Sepsis statistics should become a standard component of federal statistical reports on public health, as well as of hospital statistics.Preventive measures and evidencebased treatment should be implemented across the nation.