Artigo Revisado por pares

THYROID DISEASE AND FERTILITY

1994; Elsevier BV; Volume: 14; Issue: 4 Linguagem: Inglês

10.1016/s0889-8561(22)00338-1

ISSN

1557-8607

Autores

C. Matthew Peterson,

Tópico(s)

Ovarian function and disorders

Resumo

Hypothyroidism, hyperthyroidism, and positive thyroid autoantibody status all affect successful reproductive function. All infertile patients should undergo a TSH and prolactin evaluation. In the future, the role of subclinical hypothyroidism may be further evaluated by dynamic TRH testing. The subtle subclinical hypothyroid abnormalities now being investigated may offer an explanation for the 15% of patients with unexplained infertility. Hyperthyroidism, although not primarily considered a cause of infertility, shows diverse effects that impact successful pregnancy outcome. By understanding the basis of hyperthyroxinemic hyperemetic pregnancies in women, we may further characterize the interactions of hCG, the TSH receptor, and other thyroid-stimulating factors. The recently reported association of thyroid autoantibodies with reproductive failure suggests a possible role of T-cell dysregulation and further implicates an immune component in the etiology of reproductive failure. The reader is advised to review the intricacies of thyroid testing and physiology during pregnancy in a basic review.79

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