Genetics and Other Risk Factors for Past Concussions in Active-Duty Soldiers
2016; Mary Ann Liebert, Inc.; Volume: 34; Issue: 4 Linguagem: Inglês
10.1089/neu.2016.4480
ISSN1557-9042
AutoresMichael N. Dretsch, Noah D. Silverberg, Andrew J. Gardner, William J. Panenka, Tanja Emmerich, Gogce Crynen, Ghania Ait‐Ghezala, Helena Chaytow, Venkat Mathura, Fiona Crawford, Grant L. Iverson,
Tópico(s)Suicide and Self-Harm Studies
ResumoRisk factors for concussion in active-duty military service members are poorly understood. The present study examined the association between self-reported concussion history and genetics (apolipoprotein E [APOE], brain-derived neurotrophic factor [BDNF], and D2 dopamine receptor genes [DRD2]), trait personality measures (impulsive-sensation seeking and trait aggression-hostility), and current alcohol use. The sample included 458 soldiers who were preparing to deploy for Operation Iraqi Freedom/Operation Enduring Freedom. For those with the BDNF Met/Met genotype, 57.9% (11/19) had a history of one or more prior concussions, compared with 35.6% (154/432) of those with other BDNF genotypes (p = 0.049, odds ratio [OR] = 2.48). APOE and DRD2 genotypes were not associated with risk for past concussions. Those with the BDNF Met/Met genotype also reported greater aggression and hostility personality characteristics. When combined in a predictive model, prior military deployments, being male, and having the BDNF Met/Met genotype were independently associated with increased lifetime history of concussions in active-duty soldiers. Replication in larger independent samples is necessary to have more confidence in both the positive and negative genetic associations reported in this study.
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