CHARACTERIZATION OF THREE NEW PSYCHOTOMIMETICS
1978; Elsevier BV; Linguagem: Inglês
10.1016/b978-0-08-021938-7.50010-2
AutoresTyler Alexander, David E. Nichols,
Tópico(s)Neurotransmitter Receptor Influence on Behavior
ResumoOur present understanding of the mechanism of action of the psychotomimetic drugs has come from studies in several disciplines. Physico-chemical parameters of active compounds are easily measured and may reflect structural aspects which influence absorption and distribution in the experimental subject. In metabolic studies, the fate of these compounds has suggested possible intermediate active species, or the formation of detoxification products. Pharmacological research has revealed a complexity of neurotransmitter involvement during the course of their action. In intact animal studies the behavioral changes induced by these drugs have allowed prediction of potential activity levels in clinically untested compounds. A number of experimental animal model systems have shown a good correlation between performance modification and demonstrated human psychotomimetic potency.
Referência(s)