Metal–Organic‐Framework‐Derived Mesoporous Carbon Nanospheres Containing Porphyrin‐Like Metal Centers for Conformal Phototherapy
2016; Volume: 28; Issue: 38 Linguagem: Inglês
10.1002/adma.201602197
ISSN1521-4095
AutoresShunhao Wang, Lu Shang, Linlin Li, Yingjie Yu, Chongwei Chi, Kun Wang, Jie Zhang, Run Shi, Heyun Shen, Geoffrey I. N. Waterhouse, Sijin Liu, Jie Tian, Tierui Zhang, Huiyu Liu,
Tópico(s)Photodynamic Therapy Research Studies
ResumoMesoporous carbon nanospheres containing porphyrin-like metal centers (denoted as "PMCS") are successfully synthesized by the pyrolysis of an imidazolate framework using a mesoporous-silica protection strategy. The PMCS allow infrared and photoacoustic imaging and synergetic photothermal therapy/photodynamic therapy derived from the porphyrin-like moieties, offering the possibility of real-time monitoring of therapeutic processes and image-guided precise conformal phototherapy. PMCS thus represent a novel multifunctional theranostic platform for improved treatment efficiencies.
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