The Dynamics of Apoptotic Cell Clearance
2016; Elsevier BV; Volume: 38; Issue: 2 Linguagem: Inglês
10.1016/j.devcel.2016.06.029
ISSN1878-1551
AutoresMichael R. Elliott, Kodi S. Ravichandran,
Tópico(s)Immune cells in cancer
ResumoThe phagocytic clearance of dying cells in a tissue is a highly orchestrated series of intercellular events coordinated by a complex signaling network. Recent data from genetic, biochemical, and live-imaging approaches have greatly enhanced our understanding of the dynamics of cell clearance and how the process is orchestrated at the cellular and tissue levels. We discuss how networks regulating apoptotic cell clearance are integrated to enable a rapid, efficient, and high-capacity clearance system within tissues.
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