Improvement of mechanical properties and antibacterial activity of electrospun poly( d , l -lactide)-based mats by incorporation of ZnO- graft -poly( d , l -lactide) nanoparticles
2016; Elsevier BV; Volume: 182; Linguagem: Inglês
10.1016/j.matchemphys.2016.07.039
ISSN1879-3312
AutoresHeriberto Rodríguez‐Tobías, Graciela Morales, Daniel Grande,
Tópico(s)Graphene and Nanomaterials Applications
ResumoThe main disadvantage of electrospun mats is the propensity to bacterial adhesion associated with their peculiar nanofibrous morphological features. The aim of this work was to design electrospun poly(d,l-lactide) (PLA)-based nanofibrous mats containing ZnO-graft-PLA nanoparticles with enhanced antibacterial properties by promoting good dispersion of such PLA-modified nanoparticles within PLA nanofibers. A careful analysis of the physical properties associated with the precursory solutions was carried out in order to determine their influence on the final morphology of PLA-based mats. The presence of PLA grafts on ZnO nanoparticle surface not only benefited the antibacterial properties of PLA-based mats, but also a significant enhancement of their mechanical properties was perceived at different nanoparticle concentrations (1–5 wt-%) in comparison with those of PLA mats containing bare ZnO. These novel electrospun PLA/ZnO-graft-PLA fibrous composite mats are promising candidates for designing efficient antibacterial wound dressings with enhanced mechanical performance.
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