The Arthus Reaction
1965; Elsevier BV; Linguagem: Inglês
10.1016/b978-1-4832-3297-3.50023-x
Autores Tópico(s)Transgenic Plants and Applications
ResumoPublisher Summary This chapter provides an overview of the Arthus reaction. The Arthus phenomenon was originally described as the hemorrhagic reaction developing in the skin of a sensitized animal following the local injection of antigen. With the knowledge of the reaction that has accumulated since then, its definition should now be considered as a reaction in tissue that is produced by precipitating antibody and antigen together with accumulated polymorphonuclear leukocytes. A series of experiments were recorded on a cutaneous reaction that could be elicited in rabbits undergoing sensitization to a foreign serum. Rabbits were injected in the skin each day with 5 mL horse serum. During the first 4 days no response to the injections occurred, but on the fifth and subsequent days, edematous and finally hemorrhagic and necrotic reactions appeared in the site several hours following the injection. The phenomenon was soon repeated in many laboratories and was named the Arthus phenomenon. The direct passive Arthus reaction is identical to the active Arthus reaction except that serum-containing precipitating antibody is transferred intravenously to a normal recipient that is subsequently injected intradermally with antigen.
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