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Cyclopolymerization and Polymers with Chain-Ring Structures

1982; American Chemical Society; Linguagem: Inglês

10.1021/bk-1982-0195

1947-5918

George B. Butler, Jiři E. Kresta,

Advanced Polymer Synthesis and Characterization

Maleic anhydride and vinyl ether undergo a cyclic alternating copolymerization in a 2:1 ratio. 13C NMR has shown the polymer to contain a mixture of tetrahydrofuran and tetrahydropyran rings in an approximately 0.8:1 ratio. The copolymer shows a remarkable variety of biological activities. It is an antitumor agent; it induces the formation of interferon; it has antiviral, antibacterial, and antifungal activity; it is an anticoagulant and an anti-inflammatory agent; and it aids in the removal of plutonium from the liver. The copolymer is an immunostimulant, and appears to act by stimulating macrophages. A study of the effect of molecular weight and molecular weight distribution on toxicity and biological activity has led to the synthesis of an active copolymer with low toxicity, which is being investigated clinically as an antitumor agent.