Using Factorial Experimental Design To Prepare Size-Tuned Nanovesicles
2016; American Chemical Society; Volume: 55; Issue: 34 Linguagem: Inglês
10.1021/acs.iecr.6b01552
ISSN1520-5045
AutoresPablo García‐Manrique, María Matos, Gemma Gutiérrez, Oscar R. Estupiñán, María Carmen Blanco‐López, Carmen Pazos,
Tópico(s)Advanced Drug Delivery Systems
ResumoThe aim of this work was to prepare size-tuned nanovesicles using a modified ethanol injection method (EIM) by applying factorial experimental design. Stable size-tuned nanovesicles (liposomes and niosomes) with controlled sizes and high EE values for hydrophobic compounds (Sudan Red 7B and vitamin D3) were achieved. Equations that were able to predict the mean particle sizes, in the ranges of 55–156 nm for liposomes and 224–362 nm for niosomes with PDI values between 0.032 and 0.378, were obtained. These customized soft nanoparticles could be suitable in food, cosmetic, pharmaceutical, or medical applications, such as diagnosis or therapy.
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