Portal de Periódicos da CAPES

HIF2α–arginase axis is essential for the development of pulmonary hypertension

2016; National Academy of Sciences; Volume: 113; Issue: 31 Linguagem: Inglês

10.1073/pnas.1602978113

1091-6490

Andrew S. Cowburn, Alexi Crosby, David Macías, Cristina Branco, Renato Colaço, Mark Southwood, Mark Toshner, Laura E. Crotty Alexander, Nicholas W. Morrell, Edwin R. Chilvers, Randall S. Johnson,

High Altitude and Hypoxia

Significance The expression of hypoxia-inducible factor (HIF)-2α in pulmonary endothelium of mice influences pulmonary vascular resistance and development of hypoxic pulmonary hypertension (PH) via an arginase-1–dependent mechanism. The HIF-2α:arginase-1 axis influences the homeostatic regulation of nitric oxide synthesis in the lung. Impaired generation of this vasoactive agent contributes to the initial development and vascular remodeling process of PH.