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Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome

2016; National Academy of Sciences; Volume: 113; Issue: 32 Linguagem: Inglês

10.1073/pnas.1601745113

1091-6490

Kirstie Whitaker, Petra E. Vértes, Rafael Romero-García, František Váša, Michael Moutoussis, Gita Prabhu, Nikolaus Weiskopf, Martina F. Callaghan, Konrad Wagstyl, Timothy Rittman, Roger Tait, Cinly Ooi, John Suckling, Becky Inkster, Peter Fonagy, Raymond J. Dolan, Peter B. Jones, Ian M. Goodyer, Edward T. Bullmore, Ian Goodyer, Edward T. Bullmore, Raymond J. Dolan, Peter Fonagy, Peter B. Jones, Paul C. Fletcher, John Suckling, Nikolaus Weiskopf, Pasco Fearon, Becky Inkster, Gita Prabhu, David Bernal‐Casas, Eran Eldar, Taposhri Ganguly, Tobias U. Hauser, Konstantinos Ioannidis, Gemma Lewis, Alda Mita, Michael Moutoussis, Sharon Neufeld, Ela Polek-MacDaeid, Rafael Romero-García, Michelle St Clair, Roger Tait, Umar Toseeb, Anne‐Laura van Harmelen, Petra E. Vértes, Kirstie Whitaker, Geert‐Jan Will, Gabriel Ziegler, Jorge Zimbron, Joost Haarsma, S. Davies, Juliet D. Griffin, Michael G Hart, František Váša, Konrad Wagstyl, Cinly Ooi, Barry Widmer, Ayesha Alrumaithi, Sarah Birt, Kalia Cleridou, Hina Dadabhoy, Ashlyn Firkins, Sian Granville, Elizabeth Harding, Alexandra Hopkins, Daniel Isaacs, Janchai King, Clare Knight, Danae Kokorikou, Christina Maurice, Cleo McIntosh, Jessica Memarzia, Harriet L. Mills, Ciara O’Donnell, Sara Pantaleone, Jennifer Scott, Alison Stribling, Junaid Bhatti, Neil E. Hubbard, Natalia Ilicheva, Michael Kentell, Ben Wallis, Laura Villis,

Advanced MRI Techniques and Applications

Significance Adolescence is a period of human brain growth and high incidence of mental health disorders. Here, we show consistently in two MRI cohorts that human brain changes in adolescence were concentrated on the more densely connected hubs of the connectome (i.e., association cortical regions that mediated efficient connectivity throughout the human brain structural network). Hubs were less myelinated at 14 y but had faster rates of myelination and cortical shrinkage in the 14- to 24-y period. This topologically focused process of cortical consolidation was associated with expression of genes enriched for normal synaptic and myelin-related processes and risk of schizophrenia. Consolidation of anatomical network hubs could be important for normal and clinically disordered adolescent brain development.