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Typical metabolic changes in high producing dairy cows early postpartum and their consequences on oocyte and embryo quality

2006; Ghent University; Volume: 75; Issue: 2(S) Linguagem: Inglês

10.21825/vdt.88867

0303-9021

Jo Leroy, Tom Vanholder, G. Opsomer, A. Van Soom, P.E.J. Bols, Aart de Kruif,

Birth, Development, and Health

The ne ga ti ve ener gy ba lan ce (NEB) is cha rac te ri zed by ty pi cal bi oche mi cal chang es such as high non-este ri fied fat ty acid (NEFA), high â-hy droxy bu ty ra te (BHB) and low glu co se con cen tra ti ons.The con cen trati ons of the se me ta bo li tes were ex ten si ve ly ana lyzed in the fol li cu lar fluid of high yiel ding dai ry cows du ring NEB and were imi ta ted in in vi tro ma tu ra ti on mo dels to in ves ti ga te their ef fects on oo cy te qua li ty.The studies re vie wed in this pa per sho wed that the ty pi cal me ta bo lic chang es that oc cur du ring NEB are well re flected in the fol li cu lar fluid (FF) of the do mi nant fol li cle.Ho we ver, the oo cy te seems to be re la ti ve ly iso la ted from ex ces si ve ly high NEFA or ex ces si ve ly low glu co se con cen tra ti ons in the blood.Ne ver the less, the in vi tro ma tu ra ti on mo dels re ve a led that such me ta bo lic chang es in the FF as so ci a ted with a NEB (high NEFA and low glu co se con cen tra ti ons) are in deed toxic for the oo cy te, re sul ting in ham pe red oo cy te ma tu ra ti on, in crea sed apop to sis and ne cro sis in the cu mu lus cells, and je o par di zed de ve lop men tal com pe ten ce of the re sulting em bry os.Only in mo de ra te ly hy po gly ce mic ma tu ra ti on con di ti ons did BHB have an ad di ti ve toxic ef fect.The se in vi tro ma tu ra ti on mo dels, ba sed on in vivo ob ser va ti ons and re vie wed in this pa per, sug gest that a pe ri od of NEB may ham per the fer ti li ty of high yiel ding dai ry cows through in cre a sed NEFA and decre a sed glu co se con cen tra ti ons in the FF, di rect ly af fec ting oo cy te qua li ty.Fi nal ly, it was also de mon stra ted in our lab that the em bryo qua li ty of lac ta ting high pro du cing dai ry cows is in fe ri or com pa red to that of non-lac ta ting dai ry hei fers or beef cows.