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Antiproliferative Properties of Oleuropein in Human Osteosarcoma Cells

2016; SAGE Publishing; Volume: 11; Issue: 4 Linguagem: Inglês

10.1177/1934578x1601100418

1934-578X

José M. Morán, Olga Leal-Hernández, M.L. Canal-Macías, Raúl Roncero‐Martín, Rafael Guerrero-Bonmatty, Ignacio Aliaga, Juan Diego Pedrera Zamorano,

Edible Oils Quality and Analysis

In this study, we evaluated the antiproliferative activity on two human osteosarcoma cell lines (MG-63 and Saos2) of oleuropein, an olive oil compound traditionally found in the Mediterranean diet. Oleuropein exhibited obvious cytotoxic effects on human osteosarcoma cells in a concentration- and time-dependent manner. Statistical analysis of IC50 by the Probit regression method suggested that oleuropein had similar toxic effects on both cell lines tested (IC50 range from 247.4-475.0 µM for MG63 cells and from 798.7-359.9 µM for Saos2 cells).