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Artigo Acesso aberto Revisado por pares
BIBTEX RIS

Immune perturbations in HIV-1–infected individuals who make broadly neutralizing antibodies

2016; American Association for the Advancement of Science; Volume: 1; Issue: 1 Linguagem: Inglês

10.1126/sciimmunol.aag0851

ISSN

2470-9468

Autores

M. Anthony Moody, Isabela Pedroza‐Pacheco, Nathan Vandergrift, Cecilia Chui, Krissey E. Lloyd, Robert Parks, Kelly A. Soderberg, Ane Ogbe, Myron S. Cohen, Hua‐Xin Liao, Feng Gao, Andrew J. McMichael, David C. Montefiori, Laurent Verkoczy, Garnett Kelsoe, Jinghe Huang, Patrick R. Shea, Mark Connors, Persephone Borrow, Barton F. Haynes,

Tópico(s)

T-cell and B-cell Immunology

Resumo

Induction of broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development. bnAbs occur in some HIV-1-infected individuals and frequently have characteristics of autoantibodies. We have studied cohorts of HIV-1-infected individuals who made bnAbs and compared them with those who did not do so, and determined immune traits associated with the ability to produce bnAbs. HIV-1-infected individuals with bnAbs had a higher frequency of blood autoantibodies, a lower frequency of regulatory CD4

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