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BIBTEX RIS

Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein

2016; National Academy of Sciences; Volume: 113; Issue: 34 Linguagem: Inglês

10.1073/pnas.1610099113

ISSN

1091-6490

Autores

Wei Wang, Linh Hồ Thùy Nguyễn, Christopher Burlak, Fariba Chegini, Feng Guo, Tim Chataway, Shulin Ju, Oriana S. Fisher, David W. Miller, Debajyoti Datta, Fang Wu, Chun-Xiang Wu, Anuradha Landeru, James A. Wells, Mark Cookson, Matthew B. Boxer, Craig J. Thomas, Wei Gai, Dagmar Ringe, Gregory A. Petsko, Quyen Q. Hoang,

Tópico(s)

Botulinum Toxin and Related Neurological Disorders

Resumo

Significance The aggregation of α-synuclein (aSyn) is a pathological hallmark of Parkinson’s disease. Here we show that the enzymatic component of the innate inflammation system, known as caspase-1, hydrolyzes aSyn, rendering it aggregation-prone.

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