Pathology of Parkinson's disease
1981; Elsevier BV; Linguagem: Inglês
10.1016/b978-0-407-02295-9.50008-4
Autores Tópico(s)Neurological disorders and treatments
ResumoThis chapter discusses the current knowledge and recent discoveries in the pathology of Parkinson's disease. The chapter discusses the two main forms of Parkinsonism: (1) one with Lewy bodies and (2) one with neurofibrillary tangles. In the state of Parkinsonism, nerve cells in the substantia nigra degenerate and Lewy bodies are formed in the process. The characteristic intraneuronal inclusions named after Lewy have attracted a great deal of attention. Round or elongated eosinophilic hyaline inclusions have been described in locations outside the pigmented nuclei of the brainstem. The polymorphism of the Lewy bodies and the heterogeneity of the organelles that enter into their composition pose difficulties for chemical characterization. Although Lewy bodies are highly characteristic, they are not pathognomonic for Parkinson's disease. The Lewy body type is the classical Parkinson's disease and is by far the most common.
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