Capítulo de livro

Genetic Control of the Immune Response to Branched Synthetic Polypeptide Antigens in Inbred Mice**This research was supported by U. S. Public Health Service research grants AI 07757, AI 10032 and AM 13892 and Special Research Fellowship AI 44178 to FCG and by the American Cancer Society, California Division, research grant 505 and Dernham Junior Fellowship 162 to GFM.

1971; Elsevier BV; Linguagem: Inglês

10.1016/b978-0-12-057550-3.50044-2

Autores

Hugh O. McDevitt, Kathleen B. Bechtol, F. Carl Grumet, Graham F. Mitchell, Thomas Wegmann,

Tópico(s)

RNA Interference and Gene Delivery

Resumo

This chapter discusses specific immune response genes of guinea pigs. Two inbred guinea pig strains, 2 and 13, as well as random bred lines were used to study the genetic control of specific immune responsiveness. The PLL gene was the first specific Ir gene identified. It controls responsiveness to poly-L-lysine (PLL), poly-L-arginine, to a copolymer of L-glutamic acid and L-lysine, and to all hapten conjugates of these polypeptides. The PLL gene is found in all strain 2 guinea pigs and is lacking in strain 13 animals. Another gene designated as the "GA gene" was identified in all inbred strain 2 guinea pigs; it controlled responsiveness to a random linear copolymer containing 60% L-glutamic acid and 40% L-alanine (GA). Similarly to the PLL gene, the GA gene was not found in strain 13 guinea pigs. A third gene was identified in inbred guinea pigs. It was concerned with responsiveness to a random linear copolymer composed of 50% L-glutamic acid and 50% L-tyrosine and is called the "GT gene."

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