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BIBTEX RIS

New Cytotoxic Bibenzyl and Other Constituents from Bauhinia ungulata L. (Fabaceae)

2016; Wiley; Volume: 13; Issue: 12 Linguagem: Inglês

10.1002/cbdv.201600058

1612-1880

Leôncio M. de Sousa, Jarbas Lima de Carvalho, Horlando Carlota da Silva, Telma L. G. Lemos, Ângela M. C. Arriaga, Raimundo Braz‐Filho, Gardênia Carmen Gadelha Militão, Thiago D. S. Silva, Paulo Riceli Vasconcelos Ribeiro, Gilvandete M. P. Santiago,

Phytochemicals and Antioxidant Activities

A new bibenzyl, 2′‐hydroxy‐3,5‐dimethoxy‐4‐methylbibenzyl ( 1 ) and four known compounds identified as 2′‐hydroxy‐3,5‐dimethoxybibenzyl ( 2 ), liquiritigenin ( 3 ), guibourtinidol ( 4 ) and fisetinidol ( 5 ) were isolated from the roots of Bauhinia ungulata L. Phytochemical investigations of the stems of B . ungulata led to the isolation of the known compounds identified as liquiritigenin ( 3 ), guibourtinidol ( 4 ), fisetinidol ( 5 ), taraxerol ( 6 ), betulinic acid ( 7 ), taraxerone ( 8 ), glutinol ( 9 ), a mixture of sitosterol ( 10 ) and stigmasterol ( 11 ), pacharin ( 12 ), naringenin ( 13 ) and eriodictyol ( 14 ). The structures of these compounds were elucidated on the basis of their spectral data ( IR , MS , 1D‐ and 2D‐ NMR ). The cytotoxicity of the bibenzyl 1 has been evaluated against four human cancer cell lines, showing the IC 50 values of 4.3 and 6.5 μg ml −1 against pro‐myelocytic leukemia ( HL ‐60) and cervical adenocarcinoma ( HEP ‐2) cell lines, respectively. This article also registers for the first time the 13 C‐ NMR data of the known bibenzyl 2 .