Effect of chronic administration of cocaine and/or alcohol on plasma amino acids pattern in rats
2016; Elsevier BV; Volume: 258; Linguagem: Inglês
10.1016/j.toxlet.2016.06.1386
ISSN1879-3169
AutoresA. Marcos, Javier Orihuel, Dênis Martinez, Marcos Ucha, Ana Matas, Emilio Ambrosio, Arturo Anadón,
Tópico(s)Receptor Mechanisms and Signaling
ResumoCocaine addiction is a persistent mental illness and there is no effective therapy so far. The precise mechanisms underlying cocaine addictive responses remain unclear. A growing body of evidence suggests that ion channels in the brain reward circuits are believed to play an important role in cocaine addiction. Recently, proton has been identified as a neurotransmitter and one of the candidates for sensing proton is acid-sensing ion channels (ASICs). ASICs are highly expressed in the brain reward circuits. These channels are enriched at synaptic sites and play a critical role in synaptic transmission. Moreover, increasing evidence demonstrates that ASICs contribute to the pathogenesis of various neuropsychiatric disorders including cocaine addiction. Thus, targeting ASICs-dependent neurotransmission represents a novel therapeutic strategy for the treatment of cocaine addiction. In this chapter, we summarize the physiological and pharmacological properties of brain ASICs and their contribution to cocaine addiction.
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