Prevalence of Quinolone Resistance in Enterobacteriaceae from Sierra Leone and the Detection of qnrB Pseudogenes and Modified LexA Binding Sites
2016; American Society for Microbiology; Volume: 60; Issue: 11 Linguagem: Inglês
10.1128/aac.01576-16
ISSN1098-6596
AutoresTomasz A. Łęski, Michael Stockelman, Umaru Bangura, Daniel H. Chae, Rashid Ansumana, David A. Stenger, Gary J. Vora, Chris R. Taitt,
Tópico(s)Infections and bacterial resistance
ResumoABSTRACT A collection of 74 Enterobacteriaceae isolates found in Bo, Sierra Leone, were tested for quinolone antibiotic susceptibility and resistance mechanisms. The majority of isolates (62%) were resistant to quinolones, and 61% harbored chromosomal gyrA and/or parC mutations. Plasmid-mediated quinolone resistance genes were ubiquitous, with qnrB and aac(6′)-Ib-cr being the most prevalent. Mutated LexA binding sites were found in all qnrB1 genes, and truncated qnrB pseudogenes were found in the majority of Citrobacter isolates.
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