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Status epilepticus: Using antioxidant agents as alternative therapies

2016; Spandidos Publishing; Volume: 12; Issue: 4 Linguagem: Inglês

10.3892/etm.2016.3609

1792-1015

Liliana Carmona‐Aparicio, Cecilia Zavala‐Tecuapetla, María Eva González-Trujano, Aristides Iii Sampieri, Hortencia Montesinos-Correa, Leticia Granados-Rojas, Esaú Floriano-Sánchez, Elvia Coballase-Urrutía, Noemí Cárdenas‐Rodríguez,

Pharmacological Effects and Toxicity Studies

The epileptic state, or status epilepticus (SE), is the most serious situation manifested by individuals with epilepsy, and SE events can lead to neuronal damage. An understanding of the molecular, biochemical and physiopathological mechanisms involved in this type of neurological disease will enable the identification of specific central targets, through which novel agents may act and be useful as SE therapies. Currently, studies have focused on the association between oxidative stress and SE, the most severe epileptic condition. A number of these studies have suggested the use of antioxidant compounds as alternative therapies or adjuvant treatments for the epileptic state.