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Acyl flavone and lignan glucosides from Leontopodium leontopodioides

2016; Elsevier BV; Volume: 17; Linguagem: Inglês

10.1016/j.phytol.2016.08.006

1876-7486

Yangyang Xiao, Haihui Xie, Li Zhao, Gou Ping,

Sesquiterpenes and Asteraceae Studies

Two new acyl flavone glucosides, luteolin-4⿲-O-(6-p-hydroxybenzoyl)-β-d-glucopyranoside (leontopodioside A, 1) and luteolin-4⿲-O-[6-(2-methylbutyryl)]-β-d-glucopyranoside (leontopodioside B, 2), and a new acyl lignan glucoside, lariciresinol-9-angeloyl-4-O-β-d-glucopyranoside (leontopodioside C, 3) were isolated from the whole plants of Leontopodium leontopodioides (Asteraceae). Their structures were determined by spectroscopic and chemical methods. Compounds 1⿿3 exhibited α-glucosidase inhibitory activity with the half maximal inhibitory concentration (IC50) values of 55.6, 39.7, and 474.9 μM, respectively, in comparison with acarbose (626.3 μM).