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Detection of Helicobacter pylori resistance to clarithromycin and fluoroquinolones in Brazil: A national survey

2016; Baishideng Publishing Group; Volume: 22; Issue: 33 Linguagem: Inglês

10.3748/wjg.v22.i33.7587

2219-2840

Bruno Squarcio Fernandes Sanches, Gustavo Miranda Martins, Karine Sampaio LIMA, Bianca Della Croce Vieira Cota, Luciana Dias Moretzsohn, Laércio Tenório Ribeiro, Helenice Pankowski Breyer, Ismael Maguilnik, Aline Bessa Maia, Joffre Rezende-Filho, Ana Carolina G. Meira, Henrique Pinto, Edson J. Alves, Ramiro Mascarenhas, Raissa I. Passos, Julia Duarte de Souza, Osmar Reni Trindade, Luiz Gonzaga Vaz Coelho,

Eosinophilic Esophagitis

Antibiotic resistance is the main cause of failure in the treatment of Helicobacter pylori (H.pylori ) infection.Using molecular methods, this study investigated bacterial resistance to clarithromycin and fluoroquinolones in 490 adult patients recruited from five regions in Brazil.These patients had never been previously treated for H. pylori infection.Clarithromycin and fluoroquinolone resistance was found in 16.9% and 13.5% of patients, respectively.Resistance to both drugs was found in 4.3% of patients.The mean primary H. pylori clarithromycin resistance rate in Brazil is at the borderline for applying the standard triple therapy, and the primary fluoroquinolone resistance rate is concerning.