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Antiparasitic effect of Dinoponera quadriceps giant ant venom

2016; Elsevier BV; Volume: 120; Linguagem: Inglês

10.1016/j.toxicon.2016.08.008

1879-3150

Dânya Bandeira Lima, Paloma Leão Sousa, Alba Torres, Klinger Antônio da França Rodrigues, Clarissa Perdigão Mello, Ramon Róseo Paula Pessoa Bezerra de Menezes, Louise Donadello Tessarolo, Yves Quinet, Márcia Rosa de Oliveira, Alice Maria Costa Martins,

Venomous Animal Envenomation and Studies

Neglected tropical diseases (NTD) are treated with toxic therapy of limited efficacy. Previously, we studied the antimicrobial effect of Dinoponera quadriceps venom (DqV) against bacteria. To continue the study, we report in this short communication the antimicrobial effect of DqV against Leishmania amazonensis and Trypanosoma cruzi. DqV inhibits the promastigote forms of L. amazonensis and all T. cruzi developmental forms, with low toxicity in host cells. DqV causes cell death in T. cruzi through necrotic and apoptotic mechanisms observed by staining the cells with annexin V-FITC (AX) and propidium iodide (PI), loss of mitochondrial membrane potential by flow cytometry analyses and confocal microscopy and morphological alterations, such as loss of membrane integrity and cell shrinkage by scanning electron microscopy (SEM). In conclusion, we suggest there is an antimicrobial effect also on parasites.