A new ureido-substituted amino acid from the tubers of Gymnadenia conopsea
2016; Elsevier BV; Volume: 28; Issue: 2 Linguagem: Inglês
10.1016/j.cclet.2016.08.005
ISSN1878-5964
AutoresPeng‐Cheng Lin, Jing Yao, Jiang Wu, Jin Tian, Yi Bao, Sheng Lin,
Tópico(s)Marine Sponges and Natural Products
ResumoA new ureido-substituted amino acid, conopsamide A (1), has been isolated from an ethanolic extract of the tubers of Gymnadenia conopsea. Its structure was elucidated by extensive spectroscopic analysis, and the absolute configuration was assigned by Marfey's method. The new compound was evaluated for in vitro assay for HDAC1 (Histone Deacetylase 1) inhibitory activity.
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