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Circulating Non-coding RNA as Biomarkers in Colorectal Cancer

2016; Springer Nature; Linguagem: Inglês

10.1007/978-3-319-42059-2_9

2214-8019

Manuela Ferracin, Laura Lupini, Alessandra Mangolini, Massimo Negrini,

Circular RNAs in diseases

Recent studies suggested that colorectal cancer influences the types and quantity of nucleic acids - especially microRNAs – detected in the bloodstream. Concentration of circulating (cell-free) microRNAs, and possibly of other non-coding RNAs, could therefore serve as valuable colorectal cancer biomarker and could deliver insight into the disease process. This chapter addresses the recent discoveries on circulating microRNA and long non-coding RNA as diagnostic or prognostic biomarkers in colorectal cancer.