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BIBTEX RIS

PRODIGY: a web server for predicting the binding affinity of protein–protein complexes

2016; Oxford University Press; Volume: 32; Issue: 23 Linguagem: Inglês

10.1093/bioinformatics/btw514

ISSN

1367-4811

Autores

Li C. Xue, João Rodrigues, Panagiotis L. Kastritis, Alexandre M. J. J. Bonvin, Anna Vangone,

Tópico(s)

Enzyme Structure and Function

Resumo

Gaining insights into the structural determinants of protein-protein interactions holds the key for a deeper understanding of biological functions, diseases and development of therapeutics. An important aspect of this is the ability to accurately predict the binding strength for a given protein-protein complex. Here we present PROtein binDIng enerGY prediction (PRODIGY), a web server to predict the binding affinity of protein-protein complexes from their 3D structure. The PRODIGY server implements our simple but highly effective predictive model based on intermolecular contacts and properties derived from non-interface surface.PRODIGY is freely available at: http://milou.science.uu.nl/services/PRODIGY CONTACT: a.m.j.j.bonvin@uu.nl, a.vangone@uu.nl.

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