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Korean Ginseng Berry Fermented by Mycotoxin Non-producing <i>Aspergillus niger</i> and <i>Aspergillus oryzae</i>: Ginsenoside Analyses and Anti-proliferative Activities

2016; Pharmaceutical Society of Japan; Volume: 39; Issue: 9 Linguagem: Inglês

10.1248/bpb.b16-00239

1347-5215

Zhipeng Li, Hyung Jin Ahn, Nam Yeon Kim, Yu Na Lee, Geun Eog Ji,

Pharmacological Effects of Natural Compounds

To transform ginsenosides, Korean ginseng berry (KGB) was fermented by mycotoxin non-producing Aspergillus niger and Aspergillus oryzae. Changes of ginsenoside profile and anti-proliferative activities were observed. Results showed that A. niger tended to efficiently transform protopanaxadiol (PPD) type ginsenosides such as Rb1, Rb2, Rd to compound K while A. oryzae tended to efficiently transform protopanaxatriol (PPT) type ginsenoside Re to Rh1 via Rg1. Butanol extracts of fermented KGB showed high cytotoxicity on human adenocarcinoma HT-29 cell line and hepatocellular carcinoma HepG2 cell line while that of unfermented KGB showed little. The minimum effective concentration of niger-fermented KGB was less than 2.5 µg/mL while that of oryzae-fermented KGB was about 5 µg/mL. As A. niger is more inclined to transform PPD type ginsenosides, niger-fermented KGB showed stronger anti-proliferative activity than oryzae-fermented KGB.