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Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings

2016; Nature Portfolio; Volume: 48; Issue: 10 Linguagem: Inglês

10.1038/ng.3644

1546-1718

Nicholas Feasey, James Hadfield, Karen H. Keddy, Timothy J. Dallman, Jan Jacobs, Xiangyu Deng, Paul Wigley, Lars Barquist, Gemma C. Langridge, Theresa Feltwell, Simon R. Harris, Alison E. Mather, María Fookes, Martin Aslett, Chisomo Msefula, Samuel Kariuki, Calman A. MacLennan, Robert Onsaŕe, François‐Xavier Weill, Simon Le Hello, Anthony M. A. Smith, Michael McClelland, Prerak Desai, Christopher M. Parry, J. Cheesbrough, Neil French, Josefina Campos, José A. Chabalgoity, Laura Betancor, Katie L. Hopkins, Satheesh Nair, T. J. Humphrey, Octavie Lunguya, Tristan A. Cogan, Milagritos D. Tapia, Samba O. Sow, Sharon M. Tennant, Kristin Bornstein, Myron M. Levine, Lizeth Lacharme‐Lora, Dean Everett, Robert A. Kingsley, Julian Parkhill, Robert S. Heyderman, Gordon Dougan, Melita A. Gordon, Nicholas R. Thomson,

Bacteriophages and microbial interactions

Nicholas Feasey and colleagues report whole-genome sequence analysis of 675 isolates of Salmonella enterica serovar Enteritidis from 45 countries. They find evidence for a global epidemic clade associated with enterocolitis and two novel clades restricted to distinct regions of Africa and associated with invasive disease. An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.