Statement on a conceptual framework for the risk assessment of certain food additives re‐evaluated under Commission Regulation (EU) No 257/2010
2014; Wiley; Volume: 12; Issue: 6 Linguagem: Inglês
10.2903/j.efsa.2014.3697
ISSN1831-4732
Tópico(s)Consumer Attitudes and Food Labeling
ResumoEFSA JournalVolume 12, Issue 6 3697 StatementOpen Access Statement on a conceptual framework for the risk assessment of certain food additives re-evaluated under Commission Regulation (EU) No 257/2010 EFSA Panel on Food additives and Nutrient Sources added to Food (ANS), EFSA Panel on Food additives and Nutrient Sources added to Food (ANS)Search for more papers by this author EFSA Panel on Food additives and Nutrient Sources added to Food (ANS), EFSA Panel on Food additives and Nutrient Sources added to Food (ANS)Search for more papers by this author First published: 05 June 2014 https://doi.org/10.2903/j.efsa.2014.3697Citations: 38 Panel members: Fernando Aguilar, Riccardo Crebelli, Birgit Dusemund, Pierre Galtier, David Gott, Ursula Gundert-Remy, Jürgen König, Claude Lambré, Jean-Charles Leblanc, Alicja Mortensen, Pasquale Mosesso, Rose Martin, Dominique Parent-Massin, Agneta Oskarsson, Ivan Stankovic, Paul Tobback, Ine Waalkens-Berendsen, Rudolf Antonius Woutersen, Matthew Wright. Correspondence: fip@efsa.europa.eu Acknowledgement: The Panel wishes to thank the members of the Working Group "A" Food Additives and Nutrient Sources: Pierre Galtier, Rainer Gürtler, Ursula Gundert-Remy, Claude Lambré, Jean-Charles Leblanc, Pasquale Mosesso, Dominique Parent-Massin, Ivan Stankovic, Christina Tlustos and Matthew Wright and of the Working Group "B" Food Additives and Nutrient Sources: Fernando Aguilar, Polly Boon, Riccardo Crebelli, Birgit Dusemund, David Gott, Torben Hallas-Møller, Jürgen König, Oliver Lindtner, Daniel Marzin, Inge Meyland, Alicja Mortensen, Agneta Oskarsson, Iona Pratt †, Paul Tobback, Ine Waalkens-Berendsen and Rudolf Antonius Woutersen for the preparatory work on this scientific opinion and EFSA staff: Paolo Colombo, Ana Rincon, Alexandra Tard and Stavroula Tasiopoulou for the support provided to this scientific opinion. Adoption date: 15 May 2014 Published date: 5 June 2014 Question number: EFSA-Q-2014-00194 On request from: EFSA AboutPDF ToolsExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract The Panel on Food Additives and Nutrient Sources added to Food (ANS) provides a scientific statement presenting a conceptual framework for the risk assessment of certain food additives re-evaluated under Commission Regulation (EU) No 257/2010. This framework will be used in the evaluation made by the Panel, but the expert judgement of the scientific background, on a case-by-case basis, remains essential to reach a final conclusion. The outcome of the re-evaluation of food additives taking into account all available information is presented in the document, as well as the exposure assessment scenarios to be carried out by the Panel considering the use levels set in the legislation and the availability of adequate usage or analytical data. References Allainguillaume J, Alexander M, Bullock JM, Saunders M, Allender CJ, King G, Ford CS and Wilkinson MJ, 2006. Fitness of hybrids between rapeseed (Brassica napus) and wild Brassica rapa in natural habitats. Molecular Ecology, 15, 1175– 1184. Allnutt T, Blackburn J, Copeland J, Dennis C, Dixon J, Raybourn R, Wontner-Smith T, Chisholm J, Hugo S and Henry C, 2013. Estimates of genetically modified oilseed rape in shared farming machinery. Annals of Applied Biology, 162, 119– 130. Andersen NS, Rasmussen J and Jørgensen RB, 2010. You reap what you sow-or do you?–volunteers in organic row-sown and broadcast-sown oilseed rape fields. European Journal of Agronomy, 32, 121– 126. Andersson S and de Vicente MC, 2010. Gene flow between crops and their wild relatives. The Johns Hopkins University Press, Baltimore, MD, USA, 584 pp. Aono M, Wakiyama S, Nagatsu M, Nakajima N, Tamaoki M, Kubo A and Saji H, 2006. Detection of feral transgenic oilseed rape with multiple-herbicide resistance in Japan. Environmental Biosafety Research, 5, 77– 87. Aono M, Wakiyama S, Nagatsu M, Kaneko Y, Nishizawa T, Nakajima N, Tamaoki M, Kubo A and Saji H, 2011. Seeds of a possible natural hybrid between herbicide-resistant Brassica napus and Brassica rapa detected on a riverbank in Japan. GM Crops, 2, 1– 10. Bagavathiannen MV and Van Acker RC, 2008. Crop ferality: implications for novel trait confinement. Agriculture, Ecosystems and Environment, 127, 1– 6. Bailleul D, Ollier S, Huet S, Gardarin A and Lecomte J, 2012. Seed spillage from grain trailers on road verges during oilseed rape harvest: an experimental survey. PLoS ONE, 7, 1– 7. Baker J and Preston C, 2008. Canola (Brassica napus L.) seedbank declines rapidly in farmer-managed fields in South Australia. Australian Journal of Agricultural Research, 59, 780– 784. Bauer-Panskus A, Breckling B, Hamberger S and Then C, 2013. Cultivation-independent establishment of genetically engineered plants in natural populations: current evidence and implications for EU regulation. Environmental Sciences Europe, 25, 1– 34. Beckie HJ and Hall LM, 2008. Simple to complex: modelling crop pollen-mediated gene flow. Plant Science, 175, 615– 628. Beckie HJ and Warwick SI, 2010. Persistence of an oilseed rape transgene in the environment. Crop Protection, 29, 509– 512. Beckie HJ, Séguin-Swartz G, Nair H, Warwick SI and Johnson E, 2004. Multiple herbicide-resistant canola (Brassica napus) can be controlled by alternative herbicides. Weed Science, 52, 152– 157. Begg GS, Hockaday S, Mcnicol JW, Askew M and Squire GR, 2006. Modelling the persistence of volunteer oilseed rape (Brassica napus). Ecological Modelling, 198, 195– 207. CERA, 2010. A review of the environmental safety of the CP4 EPSPS protein. ILSI Research Foundation, Washington, DC, USA. Available at: ceragmc.org/docs/cera_publications/pub_01_2010.pdf Chardin, H., Senechal, H., Wal, J.M., Desvaux, F.X., Godfrin, D., Peltre, G., 2008. Characterization of peptidic and carbohydrate cross-reactive determinants in pollen polysensitization. Clinical and Experimental Allergy, 38, 680– 685. Charters YM, Robertson A and Squire GR, 1999. Investigation of feral oilseed rape populations, genetically modified organisms research report (No. 12). Department of the Environment, Transport and the Regions. Chèvre AM, Ammitzbøll H, Breckling B, Dietz-Pfeilstetter A, Eber F, Fargue A, Gomez-Campo C, Jenczewski E, Jørgensen R, Lavigne C, Meier M, den Nijs H, Pascher K, Seguin-Swartz G, Sweet J, Stewart N and Warwick S, 2004. A review on interspecific gene flow from oilseed rape to wild relatives. In: Introgression from genetically modified plants into wild relatives. Eds HCM Nijs, D Bartsch and J. Sweet CABI Publishing, Wallingford, UK, 235– 251. Claessen D, Gilligan CA, Lutman PJW and van den Bosch F, 2005a. Which traits promote persistence of feral GM crops? Part 1: implications of environmental stochasticity. Oikos, 110, 20– 29. Claessen D, Gilligan CA and van den Bosch F, 2005b. Which traits promote persistence of feral GM crops? Part 2: implications of metapopulation structure. Oikos, 110, 30– 42. Codex Alimentarius, 2009. Foods derived from modern biotechnology. Codex Alimentarius Commission, Joint FAO/WHO Food Standards Programme. Rome, Italy. 85 pp. COGEM (The Netherlands Commission on Genetic Modification), 2013. Genetically modified oilseed rape (Brassica napus). Aspects in relation to the environmental risk assessment and post-market environmental monitoring of import applications. COGEM advisory report (CGM/130402-01). Available at: www.cogem.net/index.cfm/en/publications/publicatie/advisory-report-genetically-modified-oilseed-rape-aspects-in-relation-to-the-environmental-risk-assesment-and-post-market-environmental-monitoring-of-import-applications Crawley MJ and Brown SL, 1995. Seed limitation and the dynamics of feral oilseed rape on the M25 motorway. Proceedings of the Royal Society B-Biological Sciences, 259, 49– 54. Crawley MJ and Brown SL, 2004. Spatially structured population dynamics in feral oilseed rape. Proceedings of the Royal Society B-Biological Sciences, 271, 1909– 1916. Crawley MJ, Hails RS, Rees M, Kohn D and Buxton J, 1993. Ecology of transgenic oilseed rape in natural habitats. Nature, 363, 620– 623. Crawley MJ, Brown SL, Hails RS, Kohn DD and Rees M, 2001. Transgenic crops in natural habitats. Nature, 409, 682– 683. Dafni A, 1992. Pollination ecology: a practical approach. Oxford University Press, Oxford, UK. Damgaard C and Kjaer C, 2009. Competitive interactions and the effect of herbivory on Bt-Brassica napus, Brassica rapa and Lolium perenne. Journal of Applied Ecology, 46, 1073– 1079. de Jong TJ and Hesse E, 2012. Selection against hybrids in mixed populations of Brassica rapa and Brassica napus: model and synthesis. New Phytologist, 194, 1134– 1142. de Jong TJ and Rong J, 2013. Crop to wild gene flow: Does more sophisticated research provide better risk assessment? Environmental Science & Policy, 27, 135– 140. de Jong TJ, Tudela Isanta M and Hesse E, 2013. Comparison of the crop species Brassica napus and wild B. rapa: characteristics relevant for building up a persistent seed bank in the soil. Seed Science Research, 23, 169– 179. De Vries J and Wackernagel W, 2002. Integration of foreign DNA during natural transformation of Acinetobacter sp. by homology-facilitated illegitimate recombination. Proceedings of the National Academy of Sciences of the USA, 99, 2094– 2099. Devos Y, De Schrijver A and Reheul D, 2009. Quantifying the introgressive hybridisation propensity between transgenic oilseed rape and its wild/weedy relatives. Environment Monitoring and Assessment, 149, 303– 322. Devos Y, Hails RS, Messéan A, Perry JN and Squire GR, 2012. Feral genetically modified herbicide tolerant oilseed rape from seed import spills: are concerns scientifically justified? Transgenic Research, 21, 1– 21. D'Hertefeldt T, Jørgensen RB and Pettersson LB, 2008. Long-term persistence of GM oilseed rape in the seedbank. Biology Letters, 4, 314– 317. Eastham K and Sweet J, 2002. Genetically modified organisms (GMOs): the significance of gene flow through pollen transfer. European Environment Agency. Available at: www.eea.europa.eu/publications/environmental_issue_report_2002_28 EC (European Commission), 2007. Directive 2007/68/EC of the European Parliament and of the Council of 27 November 2007 amending Annex IIIa to Directive 2000/13/EC of the European Parliament and of the Council as regards certain food ingredients. OJ L310, 11– 14. EFSA (European Food Safety Authority), 2004. Opinion of the Scientific Panel on Genetically Modified Organisms on a request from the Commission related to the Notification (Reference C/NL/98/11) for the placing on the market of glyphosate-tolerant oilseed rape event GT73, for import and processing, under Part C of Directive 2001/18/EC from Monsanto. The EFSA Journal 2004, 29, 1– 19. EFSA (European Food Safety Authority), 2006. Opinion of the Scientific Panel on Genetically Modified Organisms on an application (reference EFSA-GMO-UK-2004-08) for the placing on the market of products produced from glyphosate-tolerant genetically modified sugar beet H7-1, for food and feed uses, under Regulation 9EC) No1829/2003 from KWS SAAT and Monsanto, The EFSA Journal 2006, 431, 1– 18. EFSA (European Food Safety Authority), 2007. Opinion of the Scientific Panel on Genetically Modified Organisms on applications (references EFSA-GMO-UK-2005-19 and EFSA-GMO-RX-GA21) for the placing on the market of glyphosate-tolerant genetically modified maize GA21, for food and feed uses, import and processing and for renewal of the authorisation of maize GA21 as existing product, both under Regulation (EC) No 1829/2003 from Syngenta Seeds S.A.S. on behalf of Syngenta Crop Protection AG. The EFSA Journal 2007, 541, 1– 25. EFSA (European Food Safety Authority), 2008. Opinion of the Scientific Panel on Genetically Modified Organisms on an application (Reference EFSA-GMO-NL-2006-36) for the placing on the market of glyphosate-tolerant soybean MON89788 for food and feed uses, import and processing under Regulation (EC) 1829/2003 from Monsanto. The EFSA Journal 2008, 758, 1– 23. EFSA (European Food Safety Authority), 2009a. Scientific Opinion of the Panel on Genetically Modified Organisms on an application (Reference EFSA-GMO-CZ-2005-27) for the placing on the market of the insect-resistant and herbicide-tolerant genetically modified maize MON88017, for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Monsanto. The EFSA Journal 2009, 1075, 1– 28. EFSA (European Food Safety Authority), 2009b. Statement of EFSA on the consolidated presentation of the joint Scientific Opinion of the GMO and BIOHAZ Panels on the "Use of Antibiotic Resistance Genes as Marker Genes in Genetically Modified Plants" and the Scientific Opinion of the GMO Panel on "Consequences of the Opinion on the Use of Antibiotic Resistance Genes as Marker Genes in Genetically Modified Plants on Previous EFSA Assessments of Individual GM Plants". The EFSA Journal 2009, 1108, 1– 8. EFSA (European Food Safety Authority), 2012. Report on the safety analysis of oilseed rape GT73 pollen in food or as food. EFSA Supporting Publications, 2012:EN-227. EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms), 2009. Scientific Opinion on applications (EFSA-GMO-RX-GT73) for renewal of the authorisation for continued marketing of existing (1) food and food ingredients produced from oilseed rape GT73; and of (2) feed materials, feed additives and food additives produced from oilseed rape GT73, all under Regulation (EC) No 1829/2003 from Monsanto. EFSA Journal 2009; 7(12):1417, 12 pp. doi:10.2903/j.efsa.2009.1417 EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms), 2010a. Statistical considerations for the safety evaluation of GMOs. EFSA Journal 2010; 8(1):1250, 59 pp. doi:10.2903/j.efsa.2010.1250. EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms), 2010b. Scientific Opinion on the assessment of allergenicity of GM plants and microorganisms and derived food and feed. EFSA Journal 2010; 8(7):1700, 168 pp. doi:10.2903/j.efsa.2010.1700. EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms), 2010c. Guidance on the environmental risk assessment of GM plants. EFSA Journal 2010; 8(11):1879, 111 pp. doi:10.2903/j.efsa.2010.1879. EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms), 2011a. Guidance for risk assessment of food and feed from GM plants. EFSA Journal 2011; 9(5):2150, 37 pp. doi:10.2903/j.efsa.2011.2150. EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms), 2011b. Guidance on the post-market environmental monitoring (PMEM) of genetically modified plants. EFSA Journal 2011; 9(8):2316, 40 pp. doi:10.2903/j.efsa.2011.2316. EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms), 2011c. Scientific Opinion on application (EFSA-GMO-CZ-2008-54) for placing on the market of genetically modified insect resistant and herbicide tolerant maize MON 88017 for cultivation under Regulation (EC) No 1829/2003 from Monsanto. EFSA Journal 2011; 9(11):2428, 152 pp. doi:10.2903/j.efsa.2011.2428 EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms), 2012a. Scientific Opinion on an application (EFSAGMO-NL-2005-24) for the placing on the market of the herbicide tolerant genetically modified soybean 40–3-2 for cultivation under Regulation (EC) No 1829/2003 from Monsanto. EFSA Journal 2012; 10(6):2753, 110 pp. doi:10.2903/j.efsa.2012.2753 EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms), 2012b. Scientific Opinion on application (EFSA-GMO-NL-2010-78) for the placing on the market of herbicide tolerant genetically modified soybean MON 87705 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Monsanto. EFSA Journal 2012; 10(10):2909, 34 pp. doi:10.2903/j.efsa.2012.2909 EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms), 2013a. Scientific Opinion on application (EFSA-GMO-NL-2010-87) for the placing on the market of genetically modified herbicide tolerant oilseed rape GT73 for food containing or consisting of, and food produced from or containing ingredients produced from oilseed rape GT73 (with the exception of refined oil and food additives) under Regulation (EC) No 1829/2003 from Monsanto. EFSA Journal 2013; 11(2):3079, 26 pp. doi:10.2903/j.efsa.2013.3079 EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms), 2013b. Scientific Opinion on a request from the European Commission related to the prolongation of prohibition of the placing on the market of genetically modified oilseed rape event GT73 for import, processing and feed uses in Austria. EFSA Journal 2013; 11(4):3201, 38 pp. doi:10.2903/j.efsa.2013.3201. EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms), 2013c. Scientific Opinion on a request from the European Commission related to the prolongation of prohibition of the placing on the market of genetically modified oilseed rape events Ms8, Rf3 and Ms8 × Rf3 for import, processing and feed uses in Austria. EFSA Journal 2013; 11(4):3202, 38 pp. doi:10.2903/j.efsa.2013.3202. EFSA GMO Panel (EFSA Panel on Genetically Modified Organisms), 2013d. Scientific Opinion on application EFSA-GMO-UK-2007-41 for the placing on the market of herbicide-tolerant genetically modified cotton MON 88913 for food and feed uses, import and processing under Regulation (EC) No 1829/2003 from Monsanto. EFSA Journal 2013; 11(7):3311, 25 pp. doi:10.2903/j.efsa.2013.3311 Elling B, Neuffer B and Bleeker W, 2009. Sources of genetic diversity in feral oilseed rape (Brassica napus) populations. Basic and Applied Ecology, 10, 544– 553. Ellstrand NC, Prentice HC and Hancock JF, 1999. Gene flow and introgression from domesticated plants into their wild relatives. Annual Review of Ecology and Systematics, 30, 539– 563. Ellstrand NC, Meirmans P, Rong J, Bartsch D, Ghosh A, de Jong TJ, Haccou P, Lu B, Snow AA, Stewart Jr CN, Strasburg JL, van Tienderen PH, Vrieling K and Hooftman D, 2013. Introgression of crop alleles into wild or weedy populations. Annual Review of Ecology and Systematics, 44, 352– 345. FitzJohn RG, Armstrong TT, Newstrom-Lloyd LE, Wilton AD and Cochrane M, 2007. Hybridisation within Brassica and allied genera: evaluation of potential for transgene escape. Euphytica, 158, 209– 230. Fredshavn JR, Poulsen G, Huybrechts I and Rüdelsheim P, 1995. Competitiveness of transgenic oilseed rape. Transgenic Research, 4, 142– 148. Garnier A and Lecomte J, 2006. Using spatial and stage-structured invasion model to assess the spread of feral population of transgenic oilseed rape. Ecological Modelling, 194, 141– 149. Garnier A, Deville A and Lecomte J, 2006. Stochastic modelling of feral plant populations with seed immigration and road verge management. Ecological Modelling, 197, 373– 382. Gressel J, 2005. The challenges of ferality. In: Crop ferality and volunteerism. Ed J Gressel. Taylor & Francis Publishing Group, 1– 7. Gruber S, Pekrun C and Claupein W, 2004. Seed persistence of oilseed rape (Brassica napus): variation in transgenic and conventionally bred cultivars. Journal of Agricultural Science, 142, 29– 40. Gruber S, Colbach N, Barbottin A and Pekrun C, 2008. Post-harvest gene escape and approaches for minimizing it. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources, 3, 1– 17. Gulden RH, Shirtliffe SJ and Thomas AG, 2003. Harvest losses of canola (Brassica napus) cause large seed bank inputs. Weed Science, 51, 83– 86. Gulden RH, Thomas AG and Shirtliffe SJ, 2004a. Relative contribution of genotypes, seed size and environment to secondary dormancy potential in Canadian spring oilseed rape (Brassica napus). Weed Research, 44, 97– 106. Gulden RH, Thomas AG and Shirtliffe SJ, 2004b. Secondary dormancy, temperature, and burial depth regulate seedbank dynamics in canola. Weed Science, 52, 382– 388. Hails RS, Bullock JM, Morley K, Lamb C, Bell P, Horsnell R, Hodgson DJ and Thomas J, 2006. Predicting fitness changes in transgenic plants: testing a novel approach with pathogen resistant Brassicas. IOBC/WPRS Bulletin, 29, 63– 70. Hails RS and Morley K, 2005. Genes invading new populations: a risk assessment perspective. Trends in Ecology and Evolution, 20, 245– 252. Hails RS, Rees M, Kohn DD and Crawley MJ, 1997. Burial and seed survival in Brassica napus subsp. oleifera and Sinapsis arvensis including a comparison of transgenic and non-transgenic lines of the crop. Proceedings of the Royal Society B-Biological Sciences, 264, 1– 7. Hansen LB, Siegismund HR and Jørgensen RB, 2001. Introgression between oilseed rape (Brassica napus L.) and its weedy relative B. rapa L. in a natural population. Genetic Resources and Crop Evolution, 48, 621– 627. Hansen LB, Siegismund HR and Jørgensen RB, 2003. Progressive introgression between Brassica napus (oilseed rape) and B. rapa. Heredity, 91, 276– 283. Hecht M, Oehen B, Schulze J, Brodmann P and Bagutti C, 2014. Detection of feral GT73 transgenic oilseed rape (Brassica napus) along railway lines on entry routes to oilseed factories in Switzerland. Environmental Science and Pollution Research, 21, 1455– 1465. Heyn FW, 1977. Analysis of unreduced gametes in the Brassiceae by crosses between species and ploidy levels. Zeitschrift fuer Pflanzenzuechtung, 78, 13– 30. Hobson R and Bruce D, 2002. Seed loss when cutting a standing crop of oilseed rape with two types of combine harvester header. Biosystems Engineering, 81, 281– 286. Huangfu CH, Qiang S and Song SL, 2011. Performance of hybrids between transgenic oilseed rape (Brassica napus) and wild Brassica juncea: an evaluation of potential for transgene escape. Crop Protection, 30, 57– 62. Hüsken A and Dietz-Pfeilstetter A, 2007. Pollen-mediated intraspecific gene flow from herbicide resistant oilseed rape (Brassica napus L.). Transgenic Research, 16, 557– 569. Hülter N and Wackernagel W, 2008. Double illegitimate recombination events integrate DNA segments through two different mechanisms during natural transformation of Acinetobacter baylyi. Molecular Microbiology, 67, 984– 995. Jenczewski E, Ronfort J and Chèvre AM, 2003. Crop-to-wild gene flow, introgression and possible fitness effects of transgenes. Environmental Biosafety Research, 2, 9– 24. Jørgensen RB, 2007. Oilseed rape: co-existence and gene flow from wild species. Advances in Botanical Research, 45, 451– 464. Jørgensen R, Ammitzbøll H, Hansen L, Johannessen M, Andersen B and Hauser T, 2004. Gene introgression and consequences in Brassica. In: Introgression from genetically modified plants into wild relatives. Eds HCM Nijs, D Bartsch and J. Sweet CABI publishing, Wallingford, UK, 253– 277. Jørgensen RB, Hauser T, D'Hertefeldt T, Andersen NS and Hooftman D, 2009. The variability of processes involved in transgene dispersal-case studies from Brassica and related genera. Environmental Science and Pollution Research, 16, 389– 395. Kerlan MC, Chèvre AM and Eber F, 1993. Interspecific hybrids between a transgenic rapeseed (Brassica napus) and related species: cytological characterization and detection of the transgene. Genome, 36, 1099– 1106. Kim CG, 2012. Monitoring feral genetically modified oilseed rape outside cultivated areas. Biosafety, 1, 1– 2. Knispel AL and McLachlan SM, 2009. Landscape-scale distribution and persistence of genetically modified oilseed rape (Brassica napus) in Manitoba, Canada. Environmental Science and Pollution Research, 17, 13– 25. Knispel AL, McLachlan SM, Van Acker RC and Friesen LF, 2008. Gene flow and multiple herbicide resistance in escaped canola populations. Weed Science, 56, 72– 80. Kos SP, de Jong TJ and Tamis WLM, 2012. Can transgenic crops go wild? A literature study on using plant traits for weediness pre-screening. COGEM report: CGM 2012–01. Available at: www.cogem.net/index.cfm/en/publications/publicatie/can-transgenic-crops-go-wild-a-literary-study-on-using-plant-traits-for-weediness-pre-screening Liu YB, Wei W, Ma KP and Darmency H, 2010. Backcrosses to Brassica napus of hybrids between B. juncea and B. napus as a source of herbicide-resistant volunteer-like feral populations. Plant Science, 179, 459– 465. Liu Y, Wei W, Ma KP and Darmency H, 2012. Spread of introgressed insect-resistance genes in wild populations of Brassica juncea: a simulated in vivo approach. Transgenic Research, 22, 747– 756. Liu Y, Wei W, Ma K, Li J, Liang Y and Darmency H, 2013. Consequences of gene flow between oilseed rape (Brassica napus) and its relatives. Plant Science, 211, 42– 51. Londo JP, Bautista NS, Sagers CL, Lee EH and Watrud LS, 2010. Glyphosate drift promotes changes in fitness and transgene gene flow in canola (Brassica napus) and hybrids. Annals of Botany, 106, 957– 965. Londo JP, Bollman MA, Sagers CL, Lee EH and Watrud LS, 2011. Glyphosate-drift but not herbivory alters the rate of transgene flow from single and stacked trait transgenic canola (Brassica napus) to nontransgenic B. napus and B. rapa. New Phytologist, 191, 840– 849. López-Granados F and Lutman PJW, 1998. Effect of environmental conditions on the dormancy and germination of volunteer oilseed rape seed (Brassica napus). Weed Science, 46, 419– 423. Luijten SH and de Jong TJ, 2011. Hybridisation and introgression between Brassica napus and B. rapa in the Netherlands. COGEM report: CGM 2011-06. Available at: www.cogem.net/index.cfm/en/publications/publicatie/hybridisation-and-introgression-between-i-brassica-napus-i-and-i-brassica-rapa-i-in-the-netherlands Luijten SH, Schidlo N, Meirmans P and de Jong TJ, 2014. Hybridisation and introgression between Brassica napus and B. rapa in the Netherlands. Plant Biology, DOI:10.1111/plb.12197 Lutman PJW, Freeman SE and Pekrun C, 2003. The long-term persistence of seeds of oilseed rape (Brassica napus) in arable fields. Journal of Agricultural Science, 141, 231– 240. Lutman PJW, Berry K, Payne RW, Simpson E, Sweet JB, Champion GT, May MJ, Wightman P, Walker K and Lainsbury M, 2005. Persistence of seeds from crops of conventional and herbicide tolerant oilseed rape (Brassica napus). Proceedings of the Royal Society B-Biological Sciences, 272, 1909– 1915. Lutman PJW, Sweet J, Berry K, Law J, Payne R, Simpson E, Walker K and Wightman P, 2008. Weed control in conventional and herbicide tolerant winter oilseed rape (Brassica napus) grown in rotations with winter cereals in the UK. Weed Research, 48, 408– 419. Messéan A, Sausse C, Gasquez J and Darmency H, 2007. Occurrence of genetically modified oilseed rape seeds in the harvest of subsequent conventional oilseed rape over time. European Journal of Agronomy, 27, 115– 122. Mizuguti A, Yoshimura Y, Shibaike H and Matsuo K, 2011. Persistence of feral populations of Brassica napus originated from spilled seeds around the Kashima seaport in Japan. Japan International Research Center for Agricultural Sciences, 45, 181– 185. Monier J.-M, Bernillon D, Kay E, Faugier A, Rybalka O, Dessaux Y, Simonet P, and Vogel TM, 2007. Detection of potential transgenic plant DNA recipients among soil bacteria. Environmental Biosafety Research, 6, 71– 83. Monsalve, R.I., Gonzalez de la Pena, M.A., Lopez-Otin, C., Fiandor, A., Fernandez, C., Villalba, M., Rodriguez, R., 1997. Detection, isolation and complete amino acid sequence of an aeroallergenic protein from rapeseed flour. Clinical and Experimental Allergy, 27, 833– 841. Monsanto, 2010. The agronomic benefits of glyphosate in Europe-review of the benefits of glyphosate per market use. Available at: www.monsanto.com/products/Documents/glyphosate-background-materials/Agronomic%20benefits%20of%20glyphosate%20in%20Europe.pdf Morgan C, Bruce D, Child R, Ladbrooke Z and Arthur A, 1998. Genetic variation for pod shatter resistance among lines of oilseed rape developed from synthetic B. napus. Field Crops Research,
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