Inhibitory Activity of Brine Mineral Water on Cancer Cell Growth, Metastasis and Angiogenesis
2009; The Korean Society of Food and Nutrition; Volume: 22; Issue: 4 Linguagem: Inglês
ISSN
2287-4992
AutoresWan-Jae Kim, Hua Li, Taek-Joon Yoon, Jae-Man Sim, Seon-Kang Choi, Kwangho Lee,
Tópico(s)Glutathione Transferases and Polymorphisms
ResumoAbstract Brine mineral water(BMW) has recently gained attention as a new water resource due to its biological activities. In this study, BMW from the Geumjin area(Gangneung-city, Korea) was evaluated for its growth inhibition, anti-metastasis and anti-angiogenesis activity against cancer cells. The in vitro cytotoxicity was measured by CCK assay, and the anti-metastasis activity was estimated by lung metastasis in vivo . The in vitro incubation of mouse splenic cells with BMW that had been diluted more than 4-fold showed no effect on the cell growth when compared to a control group. Additionally, BMW inhibited the growth of the EL-4, L5178Y-R and colon26-M3.1 cancer cell lines in a dose-dependent manner. In vivo evaluation of the anti-metastasis activity of BMW in BALB/c mice inoculated with the colon26-M3.1 cell line revealed dose-dependent inhibition in response to treatment with samples that were diluted by up to 9 times. Finally, treatment with BMW effectively suppressed the growth of vascular endothelial growth factor(VEGF) added human umbilical vein endothelialcells. Overall, these results suggest that BMW has anti-cancer activity. Key words: brine mineral water, anti-cancer, anti-metastasis, anti-angiogenesis.
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